Skip to main content

Table 1 Characteristics and outcomes of the patients receiving NIV for non-hypercapnic AHRF

From: Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors

  No ARDS or mild ARDS (n = 47) Moderate or severe ARDS (n = 66) P
Age, mean, years 60 (± 15) 61 (± 17) 0.72
Male sex, n (%) 30 (64%) 45 (68%) 0.62
SAPS II, points* 33 (23 to 39) 41 (30 to 51) 0.0014
Immunosuppression or cancer, n (%) 17 (36%) 33 (50%) 0.15
Characteristics at admission before NIV    
Sepsis, n (%) 27 (73%) 53 (70%) 0.72
Systolic arterial pressure, mmHg 131 (± 25) 127 (± 27) 0.43
Heart rate, beats/minute 114 (± 25) 110 (± 26) 0.43
Respiratory rate, cycles/minute 33 (± 7) 33 (± 7) 0.78
Glasgow coma scale, points* 15 (15 to 15) 15 (15 to 15) 0.75
pH, units* 7.4 (7.43 to 7.49) 7.45 (7.40 to 7.48) 0.24
PaCO2, mm Hg 34.6 (± 6.3) 35.4 (± 5.0) 0.43
PaO2, mm Hg 77 (± 41) 85 (± 54) 0.43
Bicarbonates, mmol/L 25.0 (± 4.8) 24.5 (± 5.0) 0.58
Lactates, mmol/L* 1.4 (1.0 to 2.0) 1.9 (1.1 to 2.6) 0.054
At 1 h of NIV initiation    
pH* 7.46 (7.39 to 7.49) 7.42 (7.38 to 7.46) 0.03
PCO2, mm Hg 36.1 (± 6.6) 37.8 (± 7.4) 0.21
PaO2/FiO2, mm Hg* 266 (219 to 330) 124 (94 to 164) <0.0001
PEEP level, cm H2O 4.7 (± 1.1) 4.5 (± 1.1) 0.46
PS level, cm H2O* 8.0 (6.5 to 10) 8.0 (6 to 8) 0.46
Tidal volume, ml 579 (± 174) 613 (± 173) 0.37
Respiratory rate, breaths/minute* 34.5 (25 to 40) 32 (26 to 37.5) 0.45
Outcome    
Duration of NIV Day 1, hours* 6.8 [4.0 to 10.0] 5.2 [2.0 to 10.0] 0.19
Total duration of NIV, days* 2.0 [1.0 to 3.0] 1.0 [1.0 to 2.5] 0.17
Rate of NIV Failure, n (%) 16 (34%) 45 (68%) 0.0003
Length of stay in ICU, days* 8.0 [5.0 to 15.0] 10.0 [6.0 to 14.0] 0.53
ICU mortality, n (%) 7 (15%) 21 (32%) 0.04
  1. Values are given as mean (± standard deviation) or as median [IQR, 25th to 75th] for non-normally distributed variables (*).
  2. AHRF, Acute Hypoxemic Respiratory Failure; ARDS, Acute Respiratory Distress Syndrome; ICU, Intensive Care Unit; NIV, Non-Invasive Ventilation; SAPS II, Simplified Acute Physiology Score II.