Table 1 Characteristics and outcomes of the patients receiving NIV for non-hypercapnic AHRF
From: Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors
No ARDS or mild ARDS (n = 47) | Moderate or severe ARDS (n = 66) | P | |
|---|---|---|---|
Age, mean, years | 60 (± 15) | 61 (± 17) | 0.72 |
Male sex, n (%) | 30 (64%) | 45 (68%) | 0.62 |
SAPS II, points* | 33 (23 to 39) | 41 (30 to 51) | 0.0014 |
Immunosuppression or cancer, n (%) | 17 (36%) | 33 (50%) | 0.15 |
Characteristics at admission before NIV | |||
Sepsis, n (%) | 27 (73%) | 53 (70%) | 0.72 |
Systolic arterial pressure, mmHg | 131 (± 25) | 127 (± 27) | 0.43 |
Heart rate, beats/minute | 114 (± 25) | 110 (± 26) | 0.43 |
Respiratory rate, cycles/minute | 33 (± 7) | 33 (± 7) | 0.78 |
Glasgow coma scale, points* | 15 (15 to 15) | 15 (15 to 15) | 0.75 |
pH, units* | 7.4 (7.43 to 7.49) | 7.45 (7.40 to 7.48) | 0.24 |
PaCO2, mm Hg | 34.6 (± 6.3) | 35.4 (± 5.0) | 0.43 |
PaO2, mm Hg | 77 (± 41) | 85 (± 54) | 0.43 |
Bicarbonates, mmol/L | 25.0 (± 4.8) | 24.5 (± 5.0) | 0.58 |
Lactates, mmol/L* | 1.4 (1.0 to 2.0) | 1.9 (1.1 to 2.6) | 0.054 |
At 1 h of NIV initiation | |||
pH* | 7.46 (7.39 to 7.49) | 7.42 (7.38 to 7.46) | 0.03 |
PCO2, mm Hg | 36.1 (± 6.6) | 37.8 (± 7.4) | 0.21 |
PaO2/FiO2, mm Hg* | 266 (219 to 330) | 124 (94 to 164) | <0.0001 |
PEEP level, cm H2O | 4.7 (± 1.1) | 4.5 (± 1.1) | 0.46 |
PS level, cm H2O* | 8.0 (6.5 to 10) | 8.0 (6 to 8) | 0.46 |
Tidal volume, ml | 579 (± 174) | 613 (± 173) | 0.37 |
Respiratory rate, breaths/minute* | 34.5 (25 to 40) | 32 (26 to 37.5) | 0.45 |
Outcome | |||
Duration of NIV Day 1, hours* | 6.8 [4.0 to 10.0] | 5.2 [2.0 to 10.0] | 0.19 |
Total duration of NIV, days* | 2.0 [1.0 to 3.0] | 1.0 [1.0 to 2.5] | 0.17 |
Rate of NIV Failure, n (%) | 16 (34%) | 45 (68%) | 0.0003 |
Length of stay in ICU, days* | 8.0 [5.0 to 15.0] | 10.0 [6.0 to 14.0] | 0.53 |
ICU mortality, n (%) | 7 (15%) | 21 (32%) | 0.04 |