Table 4 Factors associated with 60-day mortality in the groups given monotherapy or dual therapy

Dual therapy versus monotherapy

1.14

0.86 to 1.50

0.37

SAPSII (per 10 points)

1.66

1.54 to 1.79

<.0001

Female gender

0.72

0.53 to 0.96

0.03

≥One co-morbidity

1.43

1.07 to 1.91

0.01

Antibiotic therapy on Day 2 versus Day 1

1.38

0.98 to 1.93

0.07

Antibiotic therapy on Day 3 versus Day 1

1.28

0.75 to 2.19

0.36

Steroids

0.97

0.71 to 1.32

0.83

Multivariate sensitivity analysis*

sHR

(95% CI)

P -value

Restricted to Streptococcus pneumoniae infection

1.42

0.73 to 2.77

0.31

Restricted to documented infection

1.29

0.89 to 1.89

0.18

Restricted to patients with septic shock

1.11

0.75 to 1.64

0.59