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Table 4 Factors associated with 60-day mortality in the groups given monotherapy or dual therapy

From: Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance

Multivariate analysis sHR 95% CI P- value
Dual therapy versus monotherapy 1.14 0.86 to 1.50 0.37
SAPSII (per 10 points) 1.66 1.54 to 1.79 <.0001
Female gender 0.72 0.53 to 0.96 0.03
≥One co-morbidity 1.43 1.07 to 1.91 0.01
Antibiotic therapy on Day 2 versus Day 1 1.38 0.98 to 1.93 0.07
Antibiotic therapy on Day 3 versus Day 1 1.28 0.75 to 2.19 0.36
Steroids 0.97 0.71 to 1.32 0.83
Multivariate sensitivity analysis* sHR (95% CI) P -value
Restricted to Streptococcus pneumoniae infection 1.42 0.73 to 2.77 0.31
Restricted to documented infection 1.29 0.89 to 1.89 0.18
Restricted to patients with septic shock 1.11 0.75 to 1.64 0.59
  1. *Adjusted on SAPSII, female gender, at least one co-morbidity, day of antibiotic therapy initiation and use of steroids.