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Table 3 Characteristics of 100 ICU patients receiving intravenous (IV) cefepime

From: Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy

  Cefepime neurotoxicity Rest of cohort P value
n = 15 n = 85
Age, years, mean 69 66 0.16
Male gender, n (%) 11 (73) 50 (59) 0.39
Acute kidney injury, n (%) 13 (87) 64 (75) 0.51
Chronic kidney disease, n (%) 10 (67) 30 (35) 0.042
Hemodialysis, n (%) 4 (27) 28 (33) 0.77
Peak creatinine, median (IQR) 2.8 (1.7-3.1)* 2.3 (1.5-3) 0.36
Nadir eGFR, median (IQR) 22.5 (20.8-34.3) 27.5 (18-45) 0.53
Mean daily cefepime dose, g, median (IQR) 2.5 (1.7-4)* 2.5 (2-3.5) 0.66
Cefepime duration, days, median (IQR) 5 (4.8-7.3)* 7 (4-10) 0.26
Appropriate dose reduction for renal function, n (%) 4 (29)* 64 (75) 0.001
  1. *Data available for 14 of the 15 cases of cefepime neurotoxicity. IQR, interquartile range; g, grams.