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Table 1 Baseline data

From: High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine

Variable Sham Sham + HF CPB CPB + HF ANOVA
(n = 8) (n = 6) (n = 8) (n = 6) P value
Weight (kg) 57.0 (1.4) 66.2 (4.1) 56.4 (1.4) 72.9 (1.8) 0.001
Serum creatinine (μmol/l) 138.8 (9.7) 136.2 (5.9) 132.3 (7.0) 136.8 (5.6) 0.937
Urine output (ml/kg/hour) 1.1 (0.17) 1.3 (0.22) 1.9 (0.40) 1.6 (0.30) 0.209
Creatinine clearance (ml/minute) 103.2 (8.2) 116.5 (17.1) 116.4 (12.9) 122.7 (19.9) 0.791
Creatinine clearance adjusted for body weight (ml/minute/kg) 1.7 (0.2) 1.6 (0.2) 2.1 (0.2) 1.6 (0.3) 0.327
Serum total cholesterol (mmol/l) 1.5 (0.9) 15.3 (2.5) 1.5 (0.8) 12.8 (3.4) <0.001
Mean arterial blood pressure (mmHg) 81.1 (2.6) 73.7 (1.7) 82.4 (2.4) 71.7 (1.5) 0.062
Perioperative fluid administration (ml) 5,000 (4,750 to 5,000) 5,000 (5,000 to 5,000) 5,500 (5,000 to 6,000) 5,125 (3,500 to 5,500) 0.230
Baseline haemoglobin (g/dl) 8.7 (0.4) 10.1 (0.2) 8.9 (0.3) 9.2 (0.6) 0.064
Perioperative metaraminol dosage (mg) 0 (0 to 0) 0 (0 to 0) 5.5 (0.5 to 15) 13.0 (10.0 to 17.0) 0.007
Baseline lung compliance (mmHg*l) 38.7 (1.6) 41.9 (2.0) 41.7 (6.7) 53.8 (1.6) 0.01
Baseline PaO2/FiO2 (mmHg) 464 (440 to 540) 412 (376 to 416) 454 (400 to 488) 450 (374 to 476) 0.355
Work of breathing (J/l) 1.2 (0.05) 1.1 (0.03) 1.1 (0.07) 1.0 (0.05) 0.148
  1. Data presented as mean (standard error of the mean) or median (interquartile range). Pairwise comparisons derived from analysis of variance (ANOVA) for weight were as follows: Sham–Sham + HF, −9.2 kg (95% confidence interval (CI) = −17.2 to −1.2), P = 0.016; Sham–CPB, 0.6 kg 95% CI = −5.8 to 6.9), P = 1.0; Sham–CPB + HF, −15.9 kg (95% CI = −24.3 to −7.4), P <0.001; CPB–CPB + HF, −16.7 kg (95% CI = −25.1 to −7.7), P <0.001. Pairwise comparisons derived from ANOVA for metaraminol dose were as follows: Sham–Sham + HF, 0.27 mg (95% CI = −10.4 to 10.9), P = 0.959; Sham–CPB, −11.9 mg (95% CI = −20.9 to −2.9), P = 0.012; Sham–CPB + HF, −14.1 (95% CI = −23.9 to −4.3), P = 0.006; CPB–CPB + HF, 2.3 mg (95% CI = −12.3 to 7.7), P = 0.651. CPB, cardiopulmonary bypass; HF, high-fat diet; PaO2/FiO2, partial pressure of oxygen/fraction of inspired oxygen.