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Table 1 Baseline data

From: High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine

Variable

Sham

Sham + HF

CPB

CPB + HF

ANOVA

(n = 8)

(n = 6)

(n = 8)

(n = 6)

P value

Weight (kg)

57.0 (1.4)

66.2 (4.1)

56.4 (1.4)

72.9 (1.8)

0.001

Serum creatinine (μmol/l)

138.8 (9.7)

136.2 (5.9)

132.3 (7.0)

136.8 (5.6)

0.937

Urine output (ml/kg/hour)

1.1 (0.17)

1.3 (0.22)

1.9 (0.40)

1.6 (0.30)

0.209

Creatinine clearance (ml/minute)

103.2 (8.2)

116.5 (17.1)

116.4 (12.9)

122.7 (19.9)

0.791

Creatinine clearance adjusted for body weight (ml/minute/kg)

1.7 (0.2)

1.6 (0.2)

2.1 (0.2)

1.6 (0.3)

0.327

Serum total cholesterol (mmol/l)

1.5 (0.9)

15.3 (2.5)

1.5 (0.8)

12.8 (3.4)

<0.001

Mean arterial blood pressure (mmHg)

81.1 (2.6)

73.7 (1.7)

82.4 (2.4)

71.7 (1.5)

0.062

Perioperative fluid administration (ml)

5,000 (4,750 to 5,000)

5,000 (5,000 to 5,000)

5,500 (5,000 to 6,000)

5,125 (3,500 to 5,500)

0.230

Baseline haemoglobin (g/dl)

8.7 (0.4)

10.1 (0.2)

8.9 (0.3)

9.2 (0.6)

0.064

Perioperative metaraminol dosage (mg)

0 (0 to 0)

0 (0 to 0)

5.5 (0.5 to 15)

13.0 (10.0 to 17.0)

0.007

Baseline lung compliance (mmHg*l)

38.7 (1.6)

41.9 (2.0)

41.7 (6.7)

53.8 (1.6)

0.01

Baseline PaO2/FiO2 (mmHg)

464 (440 to 540)

412 (376 to 416)

454 (400 to 488)

450 (374 to 476)

0.355

Work of breathing (J/l)

1.2 (0.05)

1.1 (0.03)

1.1 (0.07)

1.0 (0.05)

0.148

  1. Data presented as mean (standard error of the mean) or median (interquartile range). Pairwise comparisons derived from analysis of variance (ANOVA) for weight were as follows: Sham–Sham + HF, −9.2 kg (95% confidence interval (CI) = −17.2 to −1.2), P = 0.016; Sham–CPB, 0.6 kg 95% CI = −5.8 to 6.9), P = 1.0; Sham–CPB + HF, −15.9 kg (95% CI = −24.3 to −7.4), P <0.001; CPB–CPB + HF, −16.7 kg (95% CI = −25.1 to −7.7), P <0.001. Pairwise comparisons derived from ANOVA for metaraminol dose were as follows: Sham–Sham + HF, 0.27 mg (95% CI = −10.4 to 10.9), P = 0.959; Sham–CPB, −11.9 mg (95% CI = −20.9 to −2.9), P = 0.012; Sham–CPB + HF, −14.1 (95% CI = −23.9 to −4.3), P = 0.006; CPB–CPB + HF, 2.3 mg (95% CI = −12.3 to 7.7), P = 0.651. CPB, cardiopulmonary bypass; HF, high-fat diet; PaO2/FiO2, partial pressure of oxygen/fraction of inspired oxygen.
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Critical Care

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