Figure 1
Anaesthesia and cardiopulmonary bypass. (A) Mean arterial blood pressure (MABP). (B) Central venous oxygen saturation (ScVO2). (C) Global oxygen delivery (DO2) during cardiopulmonary bypass (CPB). (D) DO2 during CPB adjusted for body mass. (E) Periprocedural haemoglobin (Hb) concentrations. (F) Periprocedural partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratios. (G) Lung compliance. (H) Work of breathing. Key for line diagrams: black solid, Sham; black hatched, Sham + HF; grey solid, CPB; grey hatched, CPB + HF. Values represent mean (standard error of the mean), at least n = 6 per group. For graphs, pooled estimates for pairwise comparisons derived from analysis of variance for repeated measures and adjusted for mean baseline. Estimates for baseline values were as follows: MABP, 79 mmHg; ScVO2, 83.4%; DO2 556 ml/minute; Hb, 9.1 g/dl; PaO2/FiO2 386 mmHg, compliance 43.2 J/l. MABP: Sham–Sham + HF, 1.5 mmHg (95% CI = −5.5 to 8.5), P = 1.0; Sham–CPB, 12.6 mmHg (95% CI = 6.8 to 18.5), P <0.001; Sham–CPB + HF, 7.9 mmHg (95% CI = 0.3 to 15.4), P = 0.037; CPB–CPB + HF, −4.7 mmHg (95% CI = −3.3 to 12.8), P = 0.654; test for overall treatment effect for MABP, P <0.001; test for Time* Group interaction, P <0.001. ScVO2: Sham–Sham + HF, 3.3% (95% CI = −4.8 to 11.4), P = 1.0; Sham–CPB, 20.4% (95% CI = 11.7 to 29.0), P <0.001; Sham–CPB + HF, 15.2% (95% CI = 5.3 to 25.2), P = 0.002; CPB–CPB + HF, −5.1% (95% CI = −16.5 to 6.2), P = 1.0; test for overall treatment effect for ScVO2, P <0.001; test for Time* Group interaction, P = 0.134. Oxygen delivery: CPB–CPB + HF, 0.69 ml/minute (95% CI = −199 to 201), P = 0.994; test for Time* Group interaction, P = 0.184. Oxygen delivery index: CPB–CPB + HF, 0.95 ml/kg/minute (95% CI, −4.4 to 2.5), P = 0.534; test for Time* Group interaction, P = 0.505. Hb: test for overall treatment effect, P = 0.351; test for Time* Group interaction, P = 0.653. PaO2/FiO2: test for overall treatment effect, P = 0.393; test for Time* Group interaction, P = 0.486. Compliance: test for overall treatment effect, P = 0.381; test for Time* Group interaction, P = 0.098. Work of breathing: test for overall treatment effect, P = 0.295; test for Time* Group interaction, P = 0.086. CI, confidence interval; HF, high-fat diet.