Table 1 Methodological characteristics of 248 pediatric critical care trials (1986 to 2013)
From: Randomized controlled trials in pediatric critical care: a scoping review
Characteristics | RCTs n (%) |
|---|---|
Multicentered | 45 (18) |
Multinational | 14 (6) |
Number of children randomized | 49 (30 to 93)a |
Min 6, Max 1199b | |
Number of children included in analysis | 44 (28 to 80)a |
Min 6, Max 980b | |
Type of primary outcome | |
Laboratory or physiological | 44 (18) |
Clinical complications | 29 (12) |
Duration of ventilation | 14 (6) |
Severity of illness score | 14 (6) |
Clinical success | 13 (5) |
Process of care | 13 (5) |
Mortality | 5 (2) |
Other | 32 (13) |
Not reported | 82 (33) |
Source of funding | |
Noncommercial only | 102 (41) |
Commercial only | 28 (11) |
Both commercial and noncommercial | 12 (5) |
None | 5 (2) |
Not reported | 101 (41) |
Non-financial commercial support only | 21 (8) |
Early stopping | |
No | 79 (32) |
Yes | 34 (15) |
Futility, recruitment or funding | 23 (9) |
Benefit | 5 (2) |
Harm | 2 (1) |
Unclear | 4 (2) |
Unclear | 133 (54) |