Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

Table 3 Comparison of models for diagnosis of ARDS using single biomarkers to a combined model utilizing the top five performing biomarkers

Model	All data (100 pairs)	Enrollment day cases (91 pairs)	Severe cases only (66 pairs)
	AUC (95% CI)^a	AUC (95% CI)^a	AUC (95% CI)^a
Single marker models
SPD	0.69 (0.6, 0.76)	0.71 (0.63, 0.79)	0.72 (0.62, 0.81)
RAGE	0.64 (0.56, 0.72)	0.68 (0.6, 0.75)	0.67 (0.57, 0.76)
IL8	0.61 (0.54, 0.69)	0.63 (0.55, 0.7)	0.64 (0.55, 0.73)
CC16	0.60 (0.52, 0.68)	0.60 (0.52, 0.68)	0.64 (0.55, 0.74)
IL6	0.59 (0.52, 0.67)	0.61 (0.53, 0.69)	0.63 (0.53, 0.72)
Multivariable model (includes SPD, RAGE, IL-8, CC16, IL6)	0.75 (0.7, 0.84)	0.78 (0.74, 0.87)	0.82 (0.77, 0.9)

^aAll AUCs are bootstrap bias-corrected; all 95% CI are bootstrap CIs. AUC, area under the receiver operator characteristic curve; CI, confidence interval; ARDS, acute respiratory distress syndrome; SP-D, surfactant protein D; RAGE, receptor for advanced glycation endproducts; IL-8, interleukin 8; CC16, club cell protein-16; IL-6, interleukin 6.

ISSN: 1364-8535