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Table 2 Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) for predicting neurologic outcome in the training set (A) and test set (B) at different time points after cardiac arrest

From: A Cerebral Recovery Index (CRI) for early prognosis in patients after cardiac arrest

Time AUC CRI Predicting Sensitivity (CI) Specificity (CI) PPV (CI) NPV (CI)
A. Training set
12 h 0.83 <0.04 Poor outcome 0.27 (0.11–0.50) 1.00 (0.86–1.00) 1.00 (0.54–1.00) 0.60 (0.43–0.75)
   >0.90 Good outcome 0.13 (0.03–0.32) 1.00 (0.85–1.00) 1.00 (0.29–1.00) 0.51 (0.35–0.67)
18 h 0.69 <0.19 Poor outcome 0.28 (0.10–0.53) 1.00 (0.85–1.00) 1.00 (0.48–1.00) 0.63 (0.45–0.79)
   >0.91 Good outcome 0.05 (0.00–0.22) 1.00 (0.81–1.00) 1.00 (-) 0.46 (0.30–0.63)
24 h 0.87 <0.35 Poor outcome 0.45 (0.23–0.68) 1.00 (0.85–1.00) 1.00 (0.66–1.00) 0.68 (0.49–0.83)
   >0.61 Good outcome 0.57 (0.35–0.77) 1.00 (0.83–1.00) 1.00 (0.75–1.00) 0.67 (0.47–0.83)
36 h 0.74 <0.32 Poor outcome 0.28 (0.10–0.53) 1.00 (0.86–1.00) 1.00 (0.48–1.00) 0.65 (0.75–1.00)
   >0.91 Good outcome 0.04 (0.00–0.21) 1.00 (0.81–1.00) 1.00 (-) 0.44 (0.28–0.60)
B. Test set
12 h 0.74 <0.02 Poor outcome 0.13 (0.02–0.40) 1.00 (0.83–1.00) 1.00 (0.16–1.00) 0.60 (0.42–0.77)
   >1.00 Good outcome 0.00 (0.00–0.17) 1.00 (0.78–1.00) - 0.43 (0.26–0.60)
18 h 0.94 <0.18 Poor outcome 0.59 (0.33–0.82) 1.00 (0.85–1.00) 1.00 (0.69–1.00) 0.76 (0.56–0.90)
   >0.57 Good outcome 0.64 (0.41–0.83) 1.00 (0.80–1.00) 1.00 (0.77–1.00) 0.68 (0.46–0.85)
24 h 0.87 <0.29 Poor outcome 0.55 (0.32–0.76) 1.00 (0.86–1.00) 1.00 (0.73–1.00) 0.71 (0.53–0.85)
   >0.69 Good outcome 0.25 (0.10–0.47) 1.00 (0.85–1.00) 1.00 (0.54–1.00) 0.55 (0.38–0.70)
36 h 0.84 <0.22 Poor outcome 0.30 (0.12–0.54) 1.00 (0.86–1.00) 1.00 (0.54–1.00) 0.63 (0.46–0.78)
   >1.00 Good outcome 0.00 (0.00–0.14) 1.00 (0.83–1.00) - 0.45 (0.30–0.61)
  1. At each time point, we selected two thresholds for the Cerebral Recovery Index (CRI), one corresponding to a 100% specificity for predicting poor neurologic outcome, and one corresponding to a 100% specificity for predicting good neurologic outcome. In addition, the 95% confidence intervals (CIs) are given.
  2. The threshold of the CRI of >1.00 means that no threshold could be chosen in which good neurologic outcome was predicted correctly in any of the patients without having any false positives, resulting in a sensitivity of 0.