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Figure 5 | Critical Care

Figure 5

From: Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome

Figure 5

Production of immunoglobulin M (IgM) by mononuclear cells. Peripheral blood mononuclear cells (PBMCs) were isolated from 21 healthy volunteers, 24 patients with sepsis, 20 patients with severe sepsis and 11 patients with septic shock. PBMCs were stimulated with phytohemmaglutin (PHA) that is a selective lymphocyte agonist. Concentrations of IgM, panel (A) and of tumor necrosis factor alpha (TNFα), panel (B) were measured in supernatants. P values refer to comparisons with the respective production from PBMCs of healthy volunteers by the Kruskal-Wallis test after correction by Bonferroni. Production of IgM and of TNFα was below the limit of detection in supernatants of unstimulated PBMCs. Panel (C) shows the percentage of patients with IgM in supernatants above the limit of detection. P values of the indicated comparisons by the X2 test are provided.

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