Kinetics of immunoglobulin M (IgM) upon progression to shock. Thirty patients with severe sepsis progressed into septic shock. Serum IgM was measured immediately after start of vasopressors (day 0) until day 6. Results are presented separately for survivors (S) and for non-survivors (NS). The area under the curve of IgM of survivors (AUCS) and of non-survivors (AUCNS) is provided. In panel (A) S and NS are distinguished based on their outcome after 28 days; in panel (B) S and NS are distinguished based on their outcome at hospital discharge. The P values of comparisons between AUCS and AUCNS by Student’s t test are also given. CI, confidence interval.