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Figure 5 | Critical Care

Figure 5

From: Stress-dose hydrocortisone reduces critical illness-related corticosteroid insufficiency associated with severe traumatic brain injury in rats

Figure 5

Stress-dose hydrocortisone reduces the incidence of traumatic brain injury-induced critical illness-related corticosteroid insufficiency (CIRCI). The incidence of CIRCI in rats treated with stress-dose hydrocortisone (HC) (27.3%) was significantly lower than in injury control rats (68.8%) and rats receiving low-dose methylprednisolone (MP) (46.6%) on post-injury day 7 (Pearson Chi-square = 6.446, df = 1, P = 0.011 as compared to injury control). However, a difference was not detected between stress-dose HC-treated rats and control animals on post-injury day 3 or 14. #P = 0.02 as compared to injury control. Day 3: n = 23 from injury control, n = 23 from low-dose MP, n = 26 from stress-dose HC; Day 7: n = 16 from injury control, n = 15 from low-dose MP, n = 22 from stress-dose HC; day 14: n = 8 from injury control, n= 13 from low-dose MP, n = 17 from stress-dose HC.

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Critical Care

ISSN: 1364-8535