Effects of stress-dose hydrocortisone on neurological outcomes. Injured rats treated with stress-dose hydrocortisone (HC) had significantly lower mNSS scores at day 7 and day 14 after traumatic brain injury when compared with the injury control group. Data are presented as means ± SD. Analysis of variance: F(2,50) = 7.208, P = 0.002 for day7; post hoc Dunnett T3 test, #P = 0.000 for stress-dose HC treatment versus injury control, F(2,32) = 7.762, P = 0.002 for day 14; post hoc least significant difference test, *P = 0.006 for stress-dose HC treatment versus injury control. Day 1: n = 30 from each group; day 3: n = 23 from injury control, n = 23 from low-dose methylprednisolone (MP), n = 26 from stress-dose HC; day 7: n = 16 from injury control, n = 15 from low-dose MP, n = 22 from stress-dose HC; day 14: n = 8 from injury control, n = 10 from low-dose MP, n = 17 from stress-dose HC.