Table 3 Sensitivity, specificity, positive predictive values and negative predictive values of CPR, PCT, MR-proADM and CT-pro-ET1

From: Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality risk in critically ill children: a prospective study

Parameters	PICU risk mortality score				Organ failure (+1)
Parameters	Se	Sp	PPV	NPV	Se	Sp	PPV	NPV
CRP	0.416	0.640	0.072	0.942	0.583	0.642	0.192	0.914
PCT	0.700	0.798	0.167	0.979	0.610	0.569	0.169	0.910
MR-ProADM	0.900	0.758	0.337	0.982	0.897	0.850	0.693	0.956
CT-proET-1	0.710	0.741	0.386	0.954	0.884	0.768	0.592	0.946
	PICU risk mortality score
	Without infection				With infection
Parameters	Se	Sp	PPV	NPV	Se	Sp	PPV	NPV
CRP	0.400	0.865	0.125	0.968	0.500	0.365	0.060	0.900
PCT	0.750	0.822	0.143	0.988	0.500	0.573	0.088	0.933
MR-proADM	0.863	0.817	0.422	0.974	0.875	0.701	0.233	0.982
CT-proET-1	0.773	0.866	0.472	0.960	0.625	0.833	0.278	0.956
	Organ failure (+1)
	Without infection				With infection
Parameters	Se	Sp	PPV	NPV	Se	Sp	PPV	NPV
CRP	0.778	0.677	0.179	0.971	0.643	0.606	0.257	0.889
PCT	0.778	0.758	0.233	0.973	0.428	0.938	0.600	0.884
MR-proADM	0.898	0.877	0.759	0.952	0.895	0.742	0.500	0.961
CT-proET-1	0.918	0.894	0.789	0.962	0.842	0.492	0.320	0.917

Legend: Results obtained after applying a cross validation method to test the quality of decision rules, presented for the whole sample and for subgroups of patients with and without infection. CRP (C-reactive protein, mg/dl), PCT (procalcitonin, ng/ml), MR-pro-ADM (midregional-pro-adrenomedullin, nmol/l), CT-pro-ET-1 (C-terminal-pro-endothelin-1, pmol/l). Se: sensitivity. Sp: specificity. NPV: negative predictive value. PPV: positive predictive value.

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