index in relation to the asynchrony index based on the definition of Colombo et al (AI
) and the index for patient-ventilator interaction based on automated algorithms with automated selection of timings (NeuroSync
(A) Relationship between the the index for patient-ventilator interaction based on automated algorithms with manual selection of timings (NeuroSyncMANU) (x-axis) and the EAdi-verified asynchrony index (AIColombo) results published by Colombo et al. (y-axis) for all events. Note that the first 40% increase in NeuroSyncMANU is not associated with any change in AIColombo. After about 40% increase in NeuroSyncMANU, the two increase in proportion. The intraclass correlation coefficient between AIColombo and NeuroSyncMANU for all data where the AIColombo exceeds 10% was 0.87. (B) Relationship between the percentage of events that were classified as asynchronous with NeuroSyncMANU (x-axis) and the electrical activity of the diaphragm (EAdi)-verified AIColombo (y-axis). Illustrated NeuroSyncMANU index and AIColombo results were obtained manually by expert analysts verifying onset and termination of inspiratory efforts by EAdi. (C) Relationship between NeuroSync Index calculated with either manual (x-axis) or automatic (y-axis) determination of onset and termination of EAdi.