Characteristics | Nebulised amphotericin B (n = 59) | Standard care (n = 274) | P value |
---|---|---|---|
Age | 63 (43–76) | 63 (52–72) | 0.78 |
Gender male | 43 (73) | 189 (69) | 0.55 |
APACHE IV score | 77 (60–96) | 75 (58–92) | 0.42 |
Corticosteroid usea | 18 (31) | 75 (27) | 0.63 |
SOFA scoreb | 6 (3–8) | 5 (3–8) | 0.51 |
Days in ICU before onset of the colonisation episode | 0 (0–2) | 1 (0–3) | 0.24 |
Candida load in sputum (CFUs)c | Â | Â | <0.001 |
<10 | 9 (15) | 117 (43) | |
10-100 | 32 (54) | 102 (37) | |
>100 | 18 (31) | 55 (20) | |
Candida colonisation of the oropharynx | 50 (85) | 213 (78) | 0.23 |
Candida colonisation of the rectum | 23 (39) | 75 (27) | 0.08 |
Delay between onset of Candida colonisation in sputum and NAB start | 5 (4–7) | NA | NA |
Bacterial co-colonisation in sputum: | Â | Â | Â |
Gram-negative rodsd | 13 (22) | 83 (30) | 0.20 |
Pseudomonas species | 1 (2) | 20 (7) | 0.11 |
Gram-positive cocci | 13 (22) | 63 (23) | 0.87 |