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Table 4 Time-dependent analysis of the risk of developing severe sepsis a

From: Risk of developing severe sepsis after acute kidney injury: a population-based cohort study

Model AKI vs. non-AKI Recovery vs. non-AKI
HR (95% CI) P-value HR (95% CI) P-value
Model 5 3.44 (2.59 to 4.56) <0.001 1.61 (1.00 to 2.59) 0.049
(one year of follow-up)
Model 6 2.26 (1.83 to 2.78) <0.001 1.61 (1.09 to 2.37) 0.017
(two years of follow-up)
Model 7 2.05 (1.70 to 2.48) <0.001 1.68 (1.18 to 2.40) 0.004
(three years of follow-up)
  1. aAKI: acute kidney injury. (a) AKI group vs. non-AKI group. (b) Recovery group vs. non-AKI group). Model 5a: Adjusted for age, propensity score, admission frequency, comorbidities before index hospitalization (chronic kidney disease (CKD), cerebrovascular disease, dementia, chronic pulmonary disease and metastatic tumor), hematologic comorbidities during index hospitalization and advanced CKD. Advanced CKD is defined as patients with serum creatinine levels above 6 mg/dl and a concomitant erythropoiesis-stimulating agent prescription. Model 5b: Adjusted for age, propensity score, admission frequency, Charlson Comorbidity Index score, comorbidities before index hospitalization (cerebrovascular disease and peptic ulcer) and cardiovascular and respiratory comorbidities during index hospitalization. Model 6a: Adjusted for age, propensity score, Charlson Comorbidity Index score, admission frequency, comorbidities before index hospitalization (CKD, cerebrovascular disease, dementia and chronic obstructive pulmonary disease), metabolic and respiratory comorbidities during index hospitalization and advanced CKD. Model 6b: Adjusted for age, propensity score, admission frequency, Charlson Comorbidity Index score, comorbidities before index hospitalization (cerebrovascular disease and peptic ulcer) and cardiovascular, respiratory and hepatic comorbidities during index hospitalization. Model 7a: Adjusted for age, propensity score, Charlson Comorbidity Index score, admission frequency, comorbidities before index hospitalization (CKD, cerebrovascular disease, dementia and chronic obstructive pulmonary disease) and metabolic, hematologic and respiratory comorbidities during index hospitalization. Model 7b: Adjusted for age, propensity score, admission frequency, Charlson Comorbidity Index score, comorbidities before index hospitalization (cerebrovascular disease and peptic ulcer) and respiratory comorbidities during index hospitalization.