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Table 3 Crude and adjusted hazard ratios of severe sepsis for acute kidney injury status a

From: Risk of developing severe sepsis after acute kidney injury: a population-based cohort study

Analysis model AKI vs. non-AKI   Recovery vs. non-AKI  
HR (95% CI) P-value HR (95% CI) P-value
Univariate 2.87 (2.62 to 3.16) <0.001 2.80 (2.34 to 3.34) <0.001
Multivariate     
 Model 1 1.83 (1.57-2.13) <0.001 1.48 (1.06 to 2.06) 0.02
 Model 2 1.99 (1.71 to 2.31) <0.001   
 Model 3    1.58 (1.15 to 2.16) <0.001
 Model 4 1.95 (1.67 to 2.28) <0.001   
  1. aAKI: acute kidney injury; HR: hazard ratio. Model 1: Adjusted for age, sex and propensity score.
  2. Model 2: Adjusted for age, sex, propensity score, ICU admission, admission frequency, Charlson Comorbidity Index score, comorbidities before index hospitalization (cerebrovascular disease, dementia, chronic obstructive pulmonary disease, hemiplegia and metastatic tumor) and respiratory and hematologic comorbidities during index hospitalization. Model 3: Adjusted for age, sex, propensity score, admission frequency, Charlson Comorbidity Index score, comorbidities before index hospitalization (peptic ulcer and diabetes mellitus) and cardiovascular and respiratory comorbidities during index hospitalization. Model 4: Model 2 adjusted with subsequent advanced CKD after hospital discharge as a time-varying covariate. Advanced CKD is defined as patients with serum creatinine levels above 6 mg/dl and a concomitant erythropoiesis-stimulating agent prescription.