Skip to main content

Table 6 Semiquantitative analysis of lung and diaphragm electron microscopy a

From: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology

Groups Lung Diaphragm
  Alveolar capillary membrane Type II epithelial cells Endothelial cells Abnormal myofibril with Z-disk edema Mitochondrial injury Miscellaneous
ALIp NV 3 (2.5-3) 3 (3-4) 2 (1.5-2) 1 (1-1.5) 2 (1-1.5) 1 (1-2)
PCV 4 (3.5-4) 3 (3-4) 3 (2.5-3.5) 3 (3-4)b 2 (2-2.5) 4 (3-4)b
BIVENT-100 2 (2-3) 3 (2.5-3) 2 (2-2.5) 3 (2.5-4)b 3 (2.5-3)b 3 (3-3.5)
BIVENT-75 2 (1-2)c 2 (1.5-2)b,c 2 (1.5-2)c 2 (2-2.5) 2 (1.5-2) 2 (1.5-2.5)
BIVENT-50 2 (2-2)c 2 (1-2)b,c 2 (1.5-2)c 2 (1-2) 1 (1-2)d 1 (1-1.5)c,d
ALIexp NV 3 (2.5-3) 3 (2-3.5) 3 (3-4) 1 (1-1.5) 1 (1-1.5) 2 (1.5-2)
PCV 3 (2.5-4) 3 (3-3.5) 3 (3-3.5) 3 (2.5-3)b 3 (2-3)b 4 (3.5-4)
BIVENT-100 2 (2-3.5) 2 (2-3) 2 (2-3) 2 (1.5-2) 2 (1-2) 1 (1-1.5)c
BIVENT-75 2 (2-2) 2 (2-2)c 2 (1.5-2)b,c 2 (1.5-2) 2 (1.5-2) 1 (1-1.5)c
  BIVENT-50 2 (1-2) # 2 (2-2)c 2 (1.5-2.5) 3 (2-3)b 2 (2-3) 3 (2.5-3)
  1. aALIexp: extrapulmonary acute lung injury; ALIp: pulmonary acute lung injury; BIVENT: biphasic positive airway pressure at different rates of time-cycled controlled breaths: 100, 75 and 50 breaths/min; NV: nonventilated; PCV: pressure-controlled ventilation. Values are medians and IQRs of five animals in each group. A five-point semiquantitative severity-based scoring system was used. Pathological findings were graded as percentages of examined tissue: 0 = normal lung parenchyma, 1 = 1% to 25%, 2 = 26% to 50%, 3 = 51% to 75% and 4 = 76% to 100%. bNV, cPCV, dBIVENT-100 (P < 0.05).