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Table 5 Lung morphometry a

From: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology

 

ALIp

ALIexp

Morphometry

NV

PCV

BIVENT-100

BIVENT-75

BIVENT-50

NV

PCV

BIVENT-100

BIVENT-75

BIVENT-50

Normal (%)

64.1 ± 15.8

72.1 ± 5.5

52.2 ± 10.3b

65.2 ± 6.1

84.6 ± 2.6c,d,e

72.4 ± 4.0

69.3 ± 3.9

67.5 ± 6.2

72.0 ± 9.0

88.1 ± 1.9b,c,d,e

Collapsed (%)

33.7 ± 13.3

26.6 ± 6.3

45.5 ± 10.8b

32.9 ± 5.0

15.1 ± 2.2c,d,e

24.0 ± 5.4

27.7 ± 5.9

30.8 ± 6.7

26.7 ± 9.6

11.9 ± 1.9b,c,d,e

Hyperinflated (%)

2.1 ± 6.4

1.3 ± 2.5

2.2 ± 1.2

1.9 ± 1.4

0.3 ± 0.7

3.0 ± 3.0

3.0 ± 2.0

1.7 ± 1.3

1.3 ± 2.8

0 ± 0

  1. aALIexp: extrapulmonary acute lung injury; ALIp: pulmonary acute lung injury; BIVENT: biphasic positive airway pressure at different rates of time-cycled controlled breaths: 100, 75 and 50 breaths/min; NV: nonventilated; PCV: pressure-controlled ventilation. Data are volume fractions of the lung occupied by normal pulmonary areas, collapsed alveoli and hyperinflated structures in animals with ALIp and ALIexp. . All values were computed in ten random, noncoincident fields per rat. Values are means ± SD of six rats in each group. bPCV, cNV, dBIVENT-100, eBIVENT-75 (P < 0.05).
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Critical Care

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