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Table 5 Lung morphometry a

From: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology

  ALIp ALIexp
Morphometry NV PCV BIVENT-100 BIVENT-75 BIVENT-50 NV PCV BIVENT-100 BIVENT-75 BIVENT-50
Normal (%) 64.1 ± 15.8 72.1 ± 5.5 52.2 ± 10.3b 65.2 ± 6.1 84.6 ± 2.6c,d,e 72.4 ± 4.0 69.3 ± 3.9 67.5 ± 6.2 72.0 ± 9.0 88.1 ± 1.9b,c,d,e
Collapsed (%) 33.7 ± 13.3 26.6 ± 6.3 45.5 ± 10.8b 32.9 ± 5.0 15.1 ± 2.2c,d,e 24.0 ± 5.4 27.7 ± 5.9 30.8 ± 6.7 26.7 ± 9.6 11.9 ± 1.9b,c,d,e
Hyperinflated (%) 2.1 ± 6.4 1.3 ± 2.5 2.2 ± 1.2 1.9 ± 1.4 0.3 ± 0.7 3.0 ± 3.0 3.0 ± 2.0 1.7 ± 1.3 1.3 ± 2.8 0 ± 0
  1. aALIexp: extrapulmonary acute lung injury; ALIp: pulmonary acute lung injury; BIVENT: biphasic positive airway pressure at different rates of time-cycled controlled breaths: 100, 75 and 50 breaths/min; NV: nonventilated; PCV: pressure-controlled ventilation. Data are volume fractions of the lung occupied by normal pulmonary areas, collapsed alveoli and hyperinflated structures in animals with ALIp and ALIexp. . All values were computed in ten random, noncoincident fields per rat. Values are means ± SD of six rats in each group. bPCV, cNV, dBIVENT-100, eBIVENT-75 (P < 0.05).