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Table 4 Arterial blood gases at baseline zero end-expiratory pressure and end a

From: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology

 

ALIp

ALIexp

Arterial blood gases

PCV

BIVENT-100

BIVENT-75

BIVENT-50

PCV

BIVENT-100

BIVENT-75

BIVENT-50

Baseline ZEEP

        

PaO2 (mmHg)

177.5 ± 42.3

153.0 ± 39.2

162.0 ± 46.7

227.0 ± 56.6

149.7 ± 15.8

169.5 ± 31.8

181.8 ± 28.4

174.5 ± 26.5

PaCO2 (mmHg)

41.7 ± 5.1

42.0 ± 2.9

47.7 ± 2.3

42.2 ± 1.9

50.2 ± 6.6

43.4 ± 2.7

44.2 ± 3.2

42.1 ± 2.9

pHa

7.27 ± 0.03

7.31 ± 0.02

7.29 ± 0.02

7.30 ± 0.03

7.20 ± 0.03

7.27 ± 0.02

7.24 ± 0.04

7.29 ± 0.04

End

        

PaO2 (mmHg)

457.7 ± 35.6

458.8 ± 16.9

410.5 ± 53.1

456.2 ± 35.3

393.7 ± 30.4

350.8 ± 20.9

395.8 ± 23.7

381.3 ± 7.6

PaCO2 (mmHg)

37.8 ± 5.1

43.1 ± 2.5

44.2 ± 4.3

41.8 ± 1.0

44.1 ± 1.6

43.2 ± 1.5

47.5 ± 3.9

48.4 ± 2.0

pHa

7.27 ± 0.03

7.31 ± 0.03

7.24 ± 0.05

7.29 ± 0.02

7.21 ± 0.02

7.20 ± 0.03

7.26 ± 0.04

7.27 ± 0.03

  1. aALIexp: extrapulmonary acute lung injury; ALIp: pulmonary acute lung injury; BIVENT: biphasic positive airway pressure at different rates of time-cycled controlled breaths: 100, 75 and 50 breaths/min; PaO2: partial pressure of arterial oxygen; PaCO2: partial pressure of arterial carbon dioxide; PCV: pressure-controlled ventilation;, pHa: arterial pH; ZEEP: zero end-expiratory pressure. PaO2, PaCO2 and pHa were measured at baseline ZEEP and after one hour of mechanical ventilation at a fraction of inspired oxygen = 1.0 in animals with ALIp and ALIexp. Values are means ± SEM of six rats.