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Table 2 Baseline mechanical data a

From: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology

Parameters ALIp ALIexp
  PCV BIVENT-50 BIVENT-75 BIVENT-100 PCV BIVENT-50 BIVENT-75 BIVENT-100
RR (breaths/min) C 99 (99 to 99) 42 (25 to 49) 55 (0 to 72) 96 (65 to 97) 99 (98 to 99) 22 (0 to 43) 59 (32 to 73) 69 (48 to 96)
M 0 (0 to 13) 0 (0 to 73) 0 (0 to 0) 11.5 (0 to 48.0) 0 (0 to 30.0) 0 (0 to 0)
Phigh 0 (0 to 4) 0 (0 to 16) 0 (0 to 30.0) 1.5 (0 to 7) 0 (0 to 0) 11 (0-32)
Plow 33 (0 to 49) 0 (0 to 47) 0 (0 to 55.0)
Total 99 (99 to 99) 80 (51 to 92) 73 (73 to 73) 97 (96 to 97) 99 (98 to 99) 50 (49 to 92) 75 (73 to 111) 96 (96 to 97)
Vt (ml) C 1.7 (1.6 to 1.8) 1.4 (0.92 to 1.70) 0.7 (0 to 1.4) 1.5 (1.4 to 1.6) 1.7 (1.5 to 1.8) 1.17 (0 to 1.3) 0.7 (0.4 to 1.4) 1.3 (0.8 to 1.5)
M 0 (0 to 1.9) 0 (0 to 1.8) 0 (0 to 0) 0.8 (0 to 1.8) 0 (0 to 1.7) 0 (0 to 0)
Phigh 0 (0 to 1.7) 0 (0 to 1.2) 0 (0 to 1.6) 0.7 (0 to 1.5) 0 (0 to 0) 0.5 (0 to 1.7)
Plow 1.1 (0 to 1.5) 0 (0 to 1.7) 0 (0 to 2.2)
Total 1.7 (1.6 to 1.8) 1.5 (1.5 to 1.6) 1.5 (1.0 to 1.8) 1.6 (1.4 to 1.6) 1.7 (1.5 to 1.8) 1.6 (1.4 to 1.6) 1.5 (1.3 to 1.7) 1.3 (1.2 to 1.6)
V′e (ml/min) C 168 (159 to 177) 51 (28 to 83) 38 (0 to 101) 141 (95 to 156) 161 (130 to 182) 33 (0 to 54) 32 (23 to 102) 82 (43 to 121)
M 0 (0 to 24.8) 0 (0 to 139) 0 (0 to 0) 20 (0 to 73) 0 (0 to 52) 0 (0 to 0)
Phigh 0 (0 to 6.8) 0 (0 to 22) 0 (0 to 54) 2 (0 to 9) 0 (0 to 0) 19 (0 to 63)
Plow 40 (0 to 67) 0 (0 to 0) 0 (0 to 0) 0 (0 to 85) 0 (0 to 136)
Total 168 (159 to 177) 107 (83 to 145) 106 (72 to 139) 150 (144 to 156) 161 (130 to 182) 85 (71 to 149) 141 (102 to 160) 121 (111 to 151)
Ppeak,aw (cmH2O) C 15.6 (14.2 to 18.8) 11.8 (10.4 to 13.0) 11.4 (11 to 12.1) 15.5 (13.7 to 17.9) 13.5 (13 to 14.7) 10.8 (10.5 to 12.4) 9.8 (9.3 to 12.5) 13.3 (9.5 to 13.9)
M 11.1 (9.8 to 12.4) 11.4 (11.0 to 11.9) 15.2 (15.2 to 15.2) 12.7 (11.4 to 12.9) 10.5 (9.1 to 11.9) 9.2 (9.2 to 9.2)
Pmean,aw (cmH2O) C 9.2 (8.3 to 10.0) 7.6 (6.7 to 8.4) 7.5 (7.4 to 7.7) 10.5 (9.2 to 11.0) 8.7 (8.5 to 9.5) 7.6 (7.2 to 7.8) 8.0 (7.6 to 8.1) 9.1 (7.3 to 9.4)
M 6.6 (6.1 to 7.0) 7.1 (6.7 to 7.5) 9.1 (9.1 to 9.1) 6.8 (6.6 to 7.0) 6.8 (6.4 to 7.2) 6.8 (6.8 to 6.8)
Ti/Ttot C 0.35 (0.35 to 0.36) 0.36 (0.27 to 0.44) 0.36 (0 to 0.39) 0.50 (0.50 to 0.51) 0.36 (0.35 to 0.37) 0.27 (0 to 0.45) 0.41 (0.38 to 0.51) 0.51 (0.49 to 0.51)
PEEP 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0
PTP (cmH2O/ml) M 0 (0 to 38.7) 0 (0 to 143.2) 0 (0 to 0) 0 (0 to 8.7) 0 (0 to 54.3) 0 (0 to 0)
Phigh 0 (0 to 3.2) 0 (0 to 37.7) 0 (0 to 38.2) 0 (0 to 4.0) 0 (0 to 0) 22.0 (0 to 68.8)
Plow 64.7 (0 to 134.5) 0 (0 to 0) 0 (0 to 168.2)
Total 86.8 (76.4 to 137.7) 67.4 (0 to 143.2) 0 (0 to 38.2)b,c 40.6 (9.3 to 57.6) 90.5 (0 to 168.2) 56.4 (0 to 113.0)
P0.1 (cmH2O) M 0 (0 to 0.3) 0 (0 to 0.5) 0 (0 to 0) 0.1 (0 to 0.9) 0 (0 to 1.4) 0 (0 to 0)
Phigh 0 (0 to 1.2) 0 (0 to 0.9) 0 (0 to 0.6) 0.2 (0 to 0.7) 0 (0 to 0) 0.4 (0 to 2.2)
  Plow 0.5 (0 to 0.7) 0 (0 to 0.9) 0 (0 to 2.9)
  1. aALIexp: extrapulmonary acute lung injury; ALIp: pulmonary acute lung injury; BIVENT: biphasic positive airway pressure at different rates of time-cycled controlled breaths: 100, 75 and 50 breaths/min; C = fully controlled breaths; M = mixed, assisted breaths; P0.1: driving pressure; PCV: pressure-controlled ventilation; PEEP: positive end-expiratory pressure; Phigh = spontaneous breaths at high continuous positive airway pressure; Plow = spontaneous breaths at low continuous positive airway pressure; Pmean,aw: mean airway pressure; Ppeak,aw: peak airway pressure; PTP: pressure–time product per breath; RR: respiratory rate; V′e: minutes on ventilation; Vt: tidal volume; Ti/Ttot: inspiratory time divided by total respiratory cycle time. Values are medians and IQRs of six rats per group. bBIVENT-100, cBIVENT-75 (P < 0.05).