| Overall group | Low crowding group | Intermediate crowding group | High crowding group | P |
---|---|---|---|---|---|
(number = 770) | (number = 276) | (number = 250) | (number = 244) | ||
Number of interventions of the bundle accomplishedc | 5 (4 to 6) | 6 (5 to 7) | 6 (5 to 6) | 5 (4 to 6)ab | <0.001 |
Time to the implementationd (hours) | Â | Â | Â | Â | Â |
 Serum lactate measurementc | 1.3 (0.8) | 1.2 (0.8 to 2.5) | 1.3 (0.9 to 3.0) | 1.4 (0.9 to 3.6) | 0.023 |
 Blood culturesc | 1.2 (0.8 to 2.1) | 1.2 (0.8 to 1.9) | 1.2 (0.8 to 2.3) | 1.3 (0.9 to 2.2) | 0.109 |
 Broad-spectrum antibioticsc | 2.5 (1.7 to 3.8) | 2.4 (1.5 to 3.5) | 2.6 (1.7 to 3.9) | 2.8 (1.8 to 4.2) | 0.018 |
 Intravenous fluid challengec (n = 649) | 0.6 (0.1 to 1.5) | 0.6 (0.1 to 1.5) | 0.6 (0.1 to 1.6) | 0.8 (0.2 to 1.6) | 0.109 |
 CVP ≥8 mmHg achievedc (n = 546) | 2.9 (1.7 to 5.5) | 2.5 (1.5 to 5.0) | 2.7 (1.5 to 4.9) | 3.5 (2.0 to 6.8)ab | 0.005 |
 Use of vasopressorsc (n = 473) | 2.1 (1.1 to 3.4) | 1.8 (1.0 to 3.1) | 1.9 (1.1 to 3.1) | 2.4 (1.4 to 4.2)ab | 0.003 |
 Scvo2 ≥70% achievedc (n = 573) | 3.5 (1.9 to 6.6) | 3.3 (1.7 to 5.7) | 3.5 (2.0 to 5.8) | 4.2 (1.9 to 6.5) | 0.051 |