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Table 3 Rate of moderate and severe hypoglycaemia during the first 24 hours after ICU admission

From: Glycaemic control in Australia and New Zealand before and after the NICE-SUGAR trial: a translational study

 

Severe hypoglycaemia

Moderate hypoglycaemia

 

Glucose ≤2.2 mmol/L

Glucose ≤3.9 mmol/L

 

Before NICE-SUGAR

After NICE-SUGAR

P

Before NICE-SUGAR

After NICE-SUGAR

P

All patients

0.59% (449/76,600)

0.55% (489/88,896)

0.33

6.62% (5,076/76,600)

5.68% (5,051/88,896)

<0.0001

Surgical patients

0.26% (106/40,847)

0.23% (109/47,670)

0.35

4.48% (1,828/40,847)

3.17% (1,511/47,670)

<0.0001

Medical patients

0.96% (339/35,433)

0.93% (380/41,077)

0.65

9.12% (3,230/35,433)

8.61% (3,531/41,077)

0.012

IDDM patients

1.72% (43/2,499)

1.55% (38/2,454)

0.63

14.21% (355/2,499)

13.20% (324/2,454)

0.3

No-IDDM patients

0.57% (286/49,995)

0.52% (310/59,966)

0.22

6.79% (3,394/49,995)

5.64% (3,385/59,966)

<0.0001

Patients with >48 h ICU stay

0.63% (201/32,089)

0.64% (241/37,702)

0.83

7.85% (2,520/32,089)

6.87% (2,591/37,702)

<0.0001

Patients with <48 h ICU stay

0.56% (248/44,488)

0.48% (248/51,169)

0.12

5.74% (2,554/44,488)

4.80% (2,458/51,169)

<0.0001

NICE-SUGAR ICU

0.60% (100/16,794)

0.57% (111/19,346)

0.79

5.69% (955/16,794)

5.62% (1,087/19,346)

0.78

Not NICE-SUGAR ICU

0.58% (349/59,806)

0.54% (378/69,550)

0.34

6.89% (4,121/59,806)

5.70% (3,964/69,550)

<0.0001

Hospital level

      

Rural

0.66% (31/4,708)

0.6% (27/4,506)

0.72

6.65% (313/4,708)

6.88% (310/4,506)

0.66

Metropolitan

0.73% (83/11,414)

0.79% (104/13,128)

0.56

6.59% (752/11,414)

6.51% (854/13,128)

0.79

Tertiary

0.66% (301/45,756)

0.61% (319/52,634)

0.31

7.65% (3,500/45,756)

6.5% (3,421/52,364)

<0.0001

Private

0.23% (34/14,722)

0.21% (39/18,628)

0.68

3.47% (511/14,722)

2.5% (466/18,628)

<0.0001

  1. The data are given as percentages (number of patients with the event/number of patients with data available). ICU, Intensive Care Unit; IDDM, Insulin dependent diabetes mellitus; NICE-SUGAR, Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation.