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Table 3 Rate of moderate and severe hypoglycaemia during the first 24 hours after ICU admission

From: Glycaemic control in Australia and New Zealand before and after the NICE-SUGAR trial: a translational study

  Severe hypoglycaemia Moderate hypoglycaemia
  Glucose ≤2.2 mmol/L Glucose ≤3.9 mmol/L
  Before NICE-SUGAR After NICE-SUGAR P Before NICE-SUGAR After NICE-SUGAR P
All patients 0.59% (449/76,600) 0.55% (489/88,896) 0.33 6.62% (5,076/76,600) 5.68% (5,051/88,896) <0.0001
Surgical patients 0.26% (106/40,847) 0.23% (109/47,670) 0.35 4.48% (1,828/40,847) 3.17% (1,511/47,670) <0.0001
Medical patients 0.96% (339/35,433) 0.93% (380/41,077) 0.65 9.12% (3,230/35,433) 8.61% (3,531/41,077) 0.012
IDDM patients 1.72% (43/2,499) 1.55% (38/2,454) 0.63 14.21% (355/2,499) 13.20% (324/2,454) 0.3
No-IDDM patients 0.57% (286/49,995) 0.52% (310/59,966) 0.22 6.79% (3,394/49,995) 5.64% (3,385/59,966) <0.0001
Patients with >48 h ICU stay 0.63% (201/32,089) 0.64% (241/37,702) 0.83 7.85% (2,520/32,089) 6.87% (2,591/37,702) <0.0001
Patients with <48 h ICU stay 0.56% (248/44,488) 0.48% (248/51,169) 0.12 5.74% (2,554/44,488) 4.80% (2,458/51,169) <0.0001
NICE-SUGAR ICU 0.60% (100/16,794) 0.57% (111/19,346) 0.79 5.69% (955/16,794) 5.62% (1,087/19,346) 0.78
Not NICE-SUGAR ICU 0.58% (349/59,806) 0.54% (378/69,550) 0.34 6.89% (4,121/59,806) 5.70% (3,964/69,550) <0.0001
Hospital level       
Rural 0.66% (31/4,708) 0.6% (27/4,506) 0.72 6.65% (313/4,708) 6.88% (310/4,506) 0.66
Metropolitan 0.73% (83/11,414) 0.79% (104/13,128) 0.56 6.59% (752/11,414) 6.51% (854/13,128) 0.79
Tertiary 0.66% (301/45,756) 0.61% (319/52,634) 0.31 7.65% (3,500/45,756) 6.5% (3,421/52,364) <0.0001
Private 0.23% (34/14,722) 0.21% (39/18,628) 0.68 3.47% (511/14,722) 2.5% (466/18,628) <0.0001
  1. The data are given as percentages (number of patients with the event/number of patients with data available). ICU, Intensive Care Unit; IDDM, Insulin dependent diabetes mellitus; NICE-SUGAR, Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation.