Development and Standardization of a Furosemide Stress Test to Predict the Severity of Acute Kidney Injury

Table 3 Furosemide stress test receiver operation characteristics for progression to AKIN Stage III

A
Urine output measurement time point	ROC AUCs
	Cohort 1	Cohort 2	Combined
	n = 23	n = 54	n = 77
One hour	0.83 (0.11)	0.82 (0.07)	0.82 (0.05)
Two hours	0.87 (0.09)	0.87 (0.07)	0.87 (0.05)
Three hours	0.84 (0.09)	0.87 (0.07)	0.86 (0.05)
Four hours	0.85 (0.09)	0.87 (0.07)	0.86 (0.05)
Five hours	0.85 (0.09)	0.87 (0.07)	0.85 (0.05)
Six hours	0.85 (0.09)	0.86 (0.07)	0.85 (0.05)
B Furosemide stress test receiver operation characteristics for progression to AKIN stage III or death
Urine output measurement time point	ROC AUCs
	Cohort 1	Cohort 2	Combined
	n = 23	n = 54	n = 77
One hour	0.86 (0.11)	0.74 (0.08)	0.79 (0.06)
Two hours	0.89 (0.09)	0.76 (0.08)	0.81 (0.06)
Three hours	0.87 (0.09)	0.76 (0.08)	0.80 (0.06)
Four hours	0.87 (0.09)	0.76 (0.08)	0.80 (0.06)
Five hours	0.88 (0.09)	0.77 (0.08)	0.81 (0.06)
Six hours	0.87 (0.09)	0.76 (0.08)	0.80 (0.06)

The outcome was Acute Kidney Injury Network (AKIN) stage III only within 14 days of the FST. One hour is the first hour after the furosemide stress test (FST), two hours is the sum of the first and second hour after the FST. All measurements shown were significant at P <0.01. ROC AUC, receiver operating characteristic area under the curve.
Primary outcome was Acute Kidney Injury Network (AKIN) stage III or death within 14 days of furosemide stress test (FST). One hour is the first hour after the FST, two hours is the sum of the first and second hour after the FST. All measurements shown were significant at P <0.01. ROC AUC, receiver operating characteristic area under the curve; n, number of patients.

ISSN: 1364-8535