Cytokine secretion. Effect of TauCl on production of proinflammatory mediator IL-17A by Th17 lymphocytes. Activated lymphocytes (1 × 106 cells/ml) were preincubated with TauCl (0.1 or 0.5 mM) for 1 hour. After this, supernatants were collected and IL-17A was measured by ELISA. (A) blood; (B) spleen. Results are expressed as means ± SD. *Compared with sham control 24 hours; #compared with Clp control 24 hours; &compared with sham control 120 hours; $compared with Clp control 120 hours, all with P < 0.05 significant (n = 5).