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Table 6 Predictors of hospital mortality by univariable and multivariable logistic regression analyses.

From: Characteristics and outcomes of culture-negative versus culture-positive severe sepsis

Variablea Univariable OR (95% CI) P value Multivariable adjusted OR (95% CI)b P value
Demographics     
   Age, per year 1.02 (1.02-1.03) <0.001 1.03 (1.02-1.04) <0.001
Source of admission     
   Hospital floor versus ED 1.90 (1.46-2.48) <0.001 1.34 (0.97-1.85) 0.80
   Other ICU versus ED 1.38 (1.05-1.81) 0.02 1.24 (0.64-2.38) 0.53
Time of ICU admission     
   Per day from hospitalization 1.06 (1.03-1.09) <0.001 1.06 (1.03-1.09) <0.001
Comorbid conditions     
   Chronic kidney disease 1.51 (1.06-2.15) 0.02 1.29 (0.80-2.08) 0.29
   Hematological malignancy 2.03 (1.01-4.09) 0.048 1.40 (0.55-3.57) 0.48
Site of infection     
   Lungs 0.98 (0.75-1.27) 0.85 2.04 (1.00-4.16) 0.049
   Bones and joints 5.94 (1.25-28.09) 0.03 7.31 (1.05-50.77) 0.04
   Infective endocarditis 1.90 (0.70-5.13) 0.21 5.43 (1.41-20.87) 0.01
   Primary bacteremia 4.46 (1.20-16.56) 0.03 8.31 (1.55-44.49) 0.01
Microbiology and antimicrobials     
   Culture-positive 1.40 (1.08-1.82) 0.01 0.88 (0.59-1.31) 0.52
   Inappropriate antibiotics 1.42 (1.17-1.71) <0.001 0.86 (0.52-1.42) 0.56
Severity scores     
   APS, per point 1.07 (1.05-1.09) 0.001 1.06 (1.03-1.09) <0.001
Organ failurec     
   Renal 1.36 (1.00-1.84) 0.049 0.99 (0.64-1.55) 0.98
   Respiratory 1.31 (1.02-1.70) 0.04 0.98 (0.70-1.36) 0.90
   Cardiovascular 1.71 (1.32-2.21) <0.001 0.91 (0.57-1.44) 0.68
   Central nervous system 2.17 (1.67-2.82) <0.001 1.15 (0.80-1.65) 0.45
   Coagulation 3.02 (1.95-4.68) <0.001 2.59 (1.51-4.46) 0.001
   Hepatic 4.27 (2.28-7.98) <0.001 6.30 (2.98-13.30) <0.001
Treatment on day 1 in the ICU     
   Vasoactive agents 2.07 (1.56-2.76) <0.001 1.42 (0.88-2.30) 0.15
   Mechanical ventilation 3.17 (2.23-4.52) <0.001 1.91 (1.21-3.02) 0.005
  1. aOnly variables that were significantly associated with hospital mortality on univariable or multivariable analyses are shown; bHosmer-Lemeshow test for goodness of fit for multivariable logistic regression model: χ2 = 7.208, degrees of freedom = 8, P = 0.51; corgan failure defined as Sequential Organ Failure Assessment (SOFA) score >2 for the specified organ. OR, odds ratio; CI, confidence interval; ED, emergency department; ICU, intensive care unit; APS, Acute Physiology Score, used in place of the Acute Physiology and Chronic Health Evaluation (APACHE) II score.