Table 3 Baseline characteristics of patients with relative hyperlactatemia (lactate, 1.36 to 2.00 mM) compared with the control group (lactate, 0.01 to 1.35 mM)
From: Even Mild Hyperlactatemia Is Associated with Increased Mortality in Critically Ill Patients
Control group n= 1,255 | Relative hyperlactatemia n= 902 | P value | |
|---|---|---|---|
Age (years), mean ± SD | 54.1 ± 20.7 | 56.5 ± 19.7 | 0.009 |
Gender, female, number (%) | 478 (38.1) | 332 (36.8) | 0.54 |
APACHE II, mean ± SD | 21.5 ± 8.0 | 22.8 ± 8.4 | 0.0004 |
Admitting diagnostic category, number (%) | |||
Respiratory | 324 (25.8) | 213 (23.6) | 0.04 |
Cardiovascular | 312 (24.8) | 267 (29.6) | |
Neurologic | 123 (9.8) | 79 (8.8) | |
Other medical illness | 67 (5.3) | 40 (4.4) | |
Nonoperative trauma | 157 (12.5) | 87 (9.7) | |
Postoperative | 272 (21.7) | 216 (24.0) | |
Chronic comorbidities, number. (%) | |||
Chronic liver disease | 98 (8.0) | 97 (10.7) | 0.02 |
Chronic cardiovascular disease | 250 (20.8) | 188 (21.1) | 0.61 |
Chronic respiratory disease | 220 (17.8) | 169 (19.0) | 0.51 |
Chronic renal disease | 194 (15.7) | 137 (15.4) | 0.81 |
Chronic immunocompromised | 133 (10.8) | 95 (10.7) | 0.93 |
Cirrhosis, number (%) | 82 (6.5) | 78 (8.7) | 0.06 |
Diabetes, number (%) | 530 (42.2) | 384 (42.6) | 0.87 |
GCS, mean ± SD | 10.6 ± 4.2 | 10.2 ± 4.4 | 0.07 |
Sepsis, number (%) | 256 (20.4) | 229 (25.4) | 0.006 |
Mechanical ventilation, number (%) | 917 (73.1) | 701 (77.7) | 0.01 |
PaO2/FiO2 ratio, number (%) | |||
<200 mm Hg | 499/1247 (40.0) | 389/897 (43.4) | 0.12 |
>200 mm Hg | 748/1247 (60.0) | 508/897 (56.6) | |
Vasopressors, number (%) | 508 (40.5) | 407 (45.1) | 0.03 |
Laboratory findings, mean ± SD | |||
Bilirubin, (μM) | 38.2 ± 101.4 | 44.9 ± 94.6 | 0.13 |
Creatinine, (μM | 157.8 ± 169.3 | 158.8 ± 151.9 | 0.88 |
Lactate (mM) | 1.0 ± 0.2 | 1.7 ± 0.2 | <0.0001 |
INR | 1.3 ± 0.7 | 1.4 ± 0.7 | 0.01 |