Table 2 Youden index calculation in the whole cohort of patients with lactate within the reference range
From: Even Mild Hyperlactatemia Is Associated with Increased Mortality in Critically Ill Patients
Lactate level (mM) | Sensitivity | 95% CI | Specificity | 95% CI | LR+ | LR- | Youden index |
|---|---|---|---|---|---|---|---|
≥0.07 | 100.00 | 99.4-100.0 | 0.00 | 0.0-0.2 | 1.00 | 0 | |
>0.09 | 100.00 | 99.4-100.0 | 0.13 | 0.02-0.5 | 1.00 | 0.00 | 0.0013 |
>0.1 | 99.85 | 99.1-100.0 | 0.20 | 0.04-0.6 | 1.00 | 0.78 | 0.0005 |
>0.2 | 99.54 | 98.7-99.9 | 0.40 | 0.1-0.9 | 1.00 | 1.16 | -0.0006 |
>0.3 | 99.07 | 98.0-99.7 | 0.53 | 0.2-1.0 | 1.00 | 1.75 | -0.004 |
>0.4 | 98.61 | 97.4-99.4 | 1.06 | 0.6-1.7 | 1.00 | 1.31 | -0.0033 |
>0.5 | 97.69 | 96.2-98.7 | 2.78 | 2.0-3.7 | 1.00 | 0.83 | 0.0047 |
>0.6 | 95.52 | 93.6-97.0 | 6.76 | 5.5-8.1 | 1.02 | 0.66 | 0.0228 |
>0.7 | 92.90 | 90.6-94.8 | 12.39 | 10.8-14.2 | 1.06 | 0.57 | 0.0529 |
>0.8 | 85.96 | 83.0-88.5 | 18.82 | 16.9-20.9 | 1.06 | 0.75 | 0.0478 |
>0.9 | 79.17 | 75.8-82.2 | 25.78 | 23.6-28.1 | 1.07 | 0.81 | 0.0495 |
>1 | 70.52 | 66.8-74.0 | 36.71 | 34.3-39.2 | 1.11 | 0.80 | 0.0723 |
>1.1 | 62.35 | 58.5-66.1 | 45.79 | 43.3-48.3 | 1.15 | 0.82 | 0.0814 |
>1.2 | 57.41 | 53.5-61.3 | 54.14 | 51.6-56.7 | 1.25 | 0.79 | 0.1155 |
>1.3 | 51.08 | 47.2-55.0 | 62.16 | 59.7-64.6 | 1.35 | 0.79 | 0.1324 |
>1.4 | 41.51 | 37.7-45.4 | 69.18 | 66.8-71.5 | 1.35 | 0.85 | 0.1069 |
>1.5 | 32.87 | 29.3-36.6 | 74.82 | 72.5-77.0 | 1.31 | 0.90 | 0.0769 |
>1.6 | 25.77 | 22.4-29.3 | 80.91 | 78.8-82.9 | 1.35 | 0.92 | 0.0668 |
>1.7 | 19.44 | 16.5-22.7 | 85.22 | 83.3-87.0 | 1.32 | 0.95 | 0.0466 |
>1.8 | 11.73 | 9.4-14.5 | 89.86 | 88.2-91.3 | 1.16 | 0.98 | 0.0159 |
>1.9 | 6.02 | 4.3-8.1 | 94.76 | 93.5-95.8 | 1.15 | 0.99 | 0.0078 |
>2 | 0.00 | 0.0-0.6 | 100.00 | 99.8-100.0 | 1.00 | 0 |