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Table 5 Settings, delivered ventilation, respiratory mechanics and blood gas results according to the lung condition in active patients.

From: Feasibility study on full closed-loop control ventilation (IntelliVent-ASV) in ICU patients with acute respiratory failure: a prospective observational comparative study

 

1

Normal lung

2

ARDS

3

COPD

4

Others

P (ANOVA)

Post hoc comparison (P ≤0.05)

Number of patients

33

13

18

15

  

Number of days

76

54

57

44

  

MV (L/min)

10.1 (8.0-13.0)

12.5 (11.0-14.9)

11.1 (8.3-13.9)

9.2 (7.2-12.0)

<0.001

1 vs. 2; 2 vs.

VT/PBW (mL/kg)

8.4 (7.8-9.1)

8.1 (7.5-9.3)

9.3 (8.6-11.6)

7.7 (7.2-9.3)

<0.001

1 vs. 3; 2 vs. 3; 3 vs. 4

PEEP (cmH2O)

5 (5-5)

8 (5-10)

7 (5-10)

7 (5-10)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4

FiO2 (%)

30 (30-30)

33 (30-38)

30 (30-33)

30 (30-34)

<0.001

1 vs. 2

PINSP (cmH2O)

21 (16-26)

24 (16-28)

22 (17-36)

24 (21-28)

0.052

 

RR (breath/min)

21 (18-26)

25 (20-29)

18 (14-20)

21 (17-26)

<0.001

1 vs. 3; 2 vs. 3; 3 vs. 4

RCEXP (s)

0.66 (0.51-0.78)

0.52 (0.45-0.61)

0.86 (0.64-1.12)

0.53 (0.46-0.65)

<0.001

1 vs. 2; 1 vs. 3; 2 vs. 3; 3 vs. 4

PaO2/FiO2 (mm Hg)

322 (278-387)

213 (173-250)

273 (206-341)

253 (222-311)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4; 2 vs. 3; 2 vs. 4

PaO2 (mm Hg)

102 (85-121)

77 (70-84)

89 (72-107)

83 (75-94)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4; 2 vs. 3

pH

7.38 (7.34-7.44)

7.40 (7.35-7.43)

7.33 (7.25-7.37)

7.37 (7.30-7.42)

<0.001

1 vs. 3; 2 vs. 3; 3 vs. 4

PaCO2 (mm Hg)

32 (28-37)

37 (30-40)

41 (34-50)

36 (32-44)

<0.001

1 vs. 3; 1 vs. 4

  1. Values represent the median of all data. Comparisons used a Kruskal-Wallis analysis of variance (ANOVA) with a Dunn's post hoc test. MV, minute volume, VT/PBW, tidal volume on predicted body weight ratio, PEEP, positive end-expiratory pressure, PINSP, peak inspiratory pressure, RR, respiratory rate, RCEXP, expiratory time constant, vs., versus.