Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis

Table 1 Effect of propranolol on metabolic function in the lung following sepsis

Metabolite	Saline 6h	Propranolol 6h	Saline 24h	Propranolol 24h
ATP/ADP Ratio	1.35 +/- 0.09	1.63 +/- 0.29^a	2.03 +/- 0.47	1.67 +/- 0.24
NAD+	0.78 +/- 0.13	0.64 +/- 0.15	0.88 +/- 0.11	1.2 +/- 0.23^b
PUFA/MUFA	4.14 +/- 1.69	5.83 +/- 2.75	2.42 +/- 0.82	3.53 +/- 0.56^b

All values are reported as mean +/- S.D. and expressed as micromoles/gram of tissue except for ratio (ATP/ADP). ^aP < 0.05 when compared to saline at 6 hr. ^bP < 0.05 when compared to saline at 24 hour. (n = 5/group/timepoint). NAD⁺, nicotinamide adenine dinucleotide; PUFA/MUFA, polyunsaturated fatty acids to monounsaturated fatty acids.

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