Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats

Li, Tao; Zhu, Yu; Tian, Kunlun; Xue, Mingying; Peng, Xiaoyong; Lan, Dan; Liu, Liangming

doi:10.1186/cc12888

Critical Care

Table 2 Changes of left intraventricular systolic pressure (mmHg)

From: Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats

Group	Baseline	End of phase I	End of phase II	End of phase III	End of phase IV
6 weeks old
Female
No treatment	132.9 ± 15.3	71.8 ± 8.1	68.0 ± 4.9	64.4 ± 4.6	61.1 ± 4.4
40 mmHg	133.7 ± 15.2	72.4 ± 8.2	81.9 ± 5.9	106.0 ± 7.6**	137.7 ± 9.8**
50 mmHg	134.6 ± 20.2	73.4 ± 9.6	86.7 ± 13.8	105.4 ± 9.8**	129.6 ± 11.9**
60 mmHg	130.3 ± 14.8	72.9 ± 8.3	87.6 ± 6.3	106.5 ± 7.0**	121.4 ± 8.7**
70 mmHg	128.7 ± 22.8	70.2 ± 6.8	89.5 ± 13.5	104.2 ± 18.6**	101.9 ± 15.2**
80 mmHg	130.9 ± 14.9	72.9 ± 8.3	92.0 ± 5.9	106.3 ± 6.2**	93.4 ± 6.7**#
Male
No treatment	131.9 ± 15.0	66.4 ± 7.5	62.9 ± 4.5	59.6 ± 4.2	56.4 ± 4.0
40 mmHg	130.8 ± 14.8	65.8 ± 7.4	85.5 ± 6.1	107.3 ± 8.4**	130.7 ± 9.4**
50 mmHg	132.2 ± 13.6	65.4 ± 5.8	90.5 ± 11.9	108.5 ± 14.5**	123.8 ± 11.6**
60 mmHg	129.8 ± 14.7	64.2 ± 7.3	87.4 ± 6.2	106.4 ± 7.0**	116.7 ± 8.4**
70 mmHg	127.1 ± 11.6	62.9 ± 8.1	90.5 ± 9.8	104.6 ± 9.9**	100.9 ± 10.2**
80 mmHg	130.7 ± 14.8	63.6 ± 7.2	93.7 ± 5.3	107.3 ± 5.7*	92.5 ± 6.6**#
14 weeks old
Female
No treatment	135.6 ± 15.4	70.4 ± 8.0	66.7 ± 4.8	63.2 ± 4.5	59.9 ± 4.3
40 mmHg	133.9 ± 15.2	69.9 ± 7.9	86.0 ± 6.1	114.1 ± 8.2**	106.1 ± 7.6**
50 mmHg	128.2 ± 20.1	69.9 ± 9.0	91.1 ± 12.7	125.2 ± 17.7**	116.8 ± 16.2**
60 mmHg	133.9 ± 15.2	72.3 ± 8.2	96.1 ± 6.9	122.6 ± 8.8**	114.3 ± 8.2**
70 mmHg	134.7 ± 16.5	73.4 ± 7.6	107.4 ± 16.8	116.5 ± 16.6**	108.8 ± 16.2**
80 mmHg	132.9 ± 15.1	73.0 ± 8.3	98.3 ± 7.0	106.5 ± 7.8**	99.7 ± 7.1**
Male
No treatment	132.5 ± 15.0	74.4 ± 7.3	61.0 ± 4.3	57.8 ± 4.1	54.7 ± 3.9
40 mmHg	131.2 ± 14.9	75.2 ± 7.4	96.3 ± 6.9	105.7 ± 7.5**	98.7 ± 7.11*
50 mmHg	129.9 ± 9.7	74.3 ± 8.0	101.8 ± 13.0	115.1 ± 17.0**	108.6 ± 13.3**
60 mmHg	130.9 ± 14.8	68.8 ± 7.6	98.7 ± 7.1	113.4 ± 8.1**	107.0 ± 7.7**
70 mmHg	135.3 ± 25.1	69.9 ± 4.2	99.4 ± 12.5	107.9 ± 15.3**	103.6 ± 13.9**
80 mmHg	131.4 ± 14.9	68.0 ± 7.4	98.8 ± 6.0	98.7 ± 7.1**	95.0 ± 6.8**
1.5 years old
Female
No treatment	143.8 ± 15.9	76.8 ± 8.7	72.8 ± 5.2	68.9 ± 4.9	65.3 ± 4.7
40 mmHg	148.7 ± 15.7	77.8 ± 8.8	98.6 ± 7.1	104.7 ± 7.4**	105.8 ± 7.6**
50 mmHg	141.9 ± 19.3	77.4 ± 3.8	104.4 ± 11.4	115.5 ± 13.2**	116.4 ± 10.1**
60 mmHg	145.7 ± 16.0	78.0 ± 8.8	104.8 ± 7.5	118.2 ± 8.5**	117.7 ± 8.4**
70 mmHg	146.1 ± 20.0	79.7 ± 7.6	106.5 ± 16.0	126.4 ± 14.9**	120.5 ± 11.7**
80 mmHg	145.7 ± 16.1	78.3 ± 8.9	107.0 ± 7.1	115.3 ± 8.2**	110.5 ± 7.6**
Male
No treatment	145.4 ± 16.2	78.2 ± 8.9	74.1 ± 5.3	70.2 ± 5.0	66.5 ± 4.7
40 mmHg	148.9 ± 16.9	77.2 ± 8.7	82.6 ± 8.1	98.2 ± 7.0*	102.6 ± 7.4**
50 mmHg	146.3 ± 23.4	79.8 ± 6.5	89.3 ± 10.3	108.5 ± 11.4**	113.4 ± 11.4**
60 mmHg	145.7 ± 16.5	76.9 ± 8.7	90.9 ± 7.9	112.4 ± 8.1**	116.7 ± 8.4**
70 mmHg	148.6 ± 9.7	81.0 ± 7.8	92.5 ± 9.4	122.9 ± 15.8**	124.9 ± 11.7**
80 mmHg	147.8 ± 16.8	79.0 ± 8.9	94.8 ± 6.1	111.2 ± 8.0**	114.7 ± 8.2**

Data are mean ± standard deviation (n = 8/group). No treatment, no fluid infusion group control. Analysis of variance showed there were significant differences in the changes of left intraventricular systolic pressure (LVSP) between ages and different target resuscitation pressures, but no significant differences between sexes. Concretely, as age increases, the baseline LVSP is gradually increased. LVSP at the end of phases I and II had no significance between ages, sexes and pressures, but at the end of phases III and IV there were significant differences between ages and resuscitation pressures but no significant differences between sexes (P < 0.01).*P < 0.05; **P < 0.01 versus no treatment group; #P < 0.05, ##P < 0.01 versus 40 mmHg group (post-hoc Tukey test).

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com