Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats

Li, Tao; Zhu, Yu; Tian, Kunlun; Xue, Mingying; Peng, Xiaoyong; Lan, Dan; Liu, Liangming

doi:10.1186/cc12888

Critical Care

Table 1 Changes of mean arterial pressure (mmHg)

From: Ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages and sexes of rats

Group	Baseline	End of phase I	End of phase II	End of phase III	End of phase IV
6 weeks old
Female
No treatment	103.2 ± 10.2	39.6 ± 3.5	37.5 ± 1.8	35.6 ± 1.7	33.8 ± 1.6
40 mmHg	104.5 ± 11.2	41.2 ± 3.6	42.4 ± 2.1	83.6 ± 4.1**	82.8 ± 4.1**
50 mmHg	102.8 ± 8.5	39.5 ± 3.5	50.2 ± 2.7	85.5 ± 4.8**	90.6 ± 4.7*#
60 mmHg	104.6 ± 9.5	40.2 ± 3.5	62.8 ± 3.1	80.7 ± 4.0**	79.8 ± 3.9**
70 mmHg	106.3 ± 11.0	41.0 ± 3.6	71.5 ± 3.7	81.7 ± 3.6**	70.9 ± 3.5**
80 mmHg	108.3 ± 12.0	40.2 ± 3.5	71.4 ± 3.5	82.7 ± 3.1**	62.1 ± 3.0**
Male
No treatment	104.2 ± 8.6	39.6 ± 3.5	37.5 ± 1.8	35.6 ± 1.7	33.9 ± 1.6
40 mmHg	105.2 ± 8.6	41.6 ± 3.7	42.5 ± 2.1	78.0 ± 3.8**	76.0 ± 3.7**
50 mmHg	102.3 ± 5.9	43.2 ± 3.8	51.6 ± 2.7	89.1 ± 4.4**	86.8 ± 4.3**#
60 mmHg	100.8 ± 6.8	41.5 ± 3.7	62.8 ± 3.1	85.5 ± 4.2**	79.7 ± 3.9**
70 mmHg	104.3 ± 9.4	42.2 ± 3.7	70.5 ± 3.7	76.0 ± 3.8**	70.8 ± 3.5**
80 mmHg	102.3 ± 10.2	38.9 ± 3.4	71.4 ± 3.5	76.5 ± 3.3**	62.0 ± 3.0**#
14 weeks old
Female
No treatment	107.8 ± 11.3	42.2 ± 3.7	40.0 ± 1.9	38.0 ± 1.8	36.1 ± 1.7
40 mmHg	108.6 ± 9.4	39.6 ± 3.5	42.4 ± 2.1	81.8 ± 3.5**	72.5 ± 3.6**
50 mmHg	106.3 ± 10.2	43.6 ± 3.9	50.8 ± 2.7	85.8 ± 4.8**	96.7 ± 4.8**##
60 mmHg	107.5 ± 9.2	41.1 ± 3.6	62.7 ± 3.1	86.8 ± 4.4**	90.7 ± 4.5**##
70 mmHg	108.9 ± 9.5	43.6 ± 3.8	69.2 ± 3.6	86.3 ± 4.3**	77.6 ± 3.9**
80 mmHg	109.8 ± 8.6	40.1 ± 3.5	81.4 ± 4.0	75.5 ± 3.7**	67.9 ± 3.3**
Male
No treatment	110.2 ± 10.2	40.9 ± 3.6	38.7 ± 1.9	36.8 ± 1.8	34.9 ± 1.7
40 mmHg	109.8 ± 11.2	40.1 ± 3.5	42.4 ± 2.1	76.0 ± 3.2**	71.8 ± 3.5**
50 mmHg	110.3 ± 8.8	40.2 ± 3.5	49.5 ± 2.6	85.1 ± 4.4**	95.7 ± 4.8**##
60 mmHg	107.5 ± 8.2	41.2 ± 3.6	62.9 ± 3.1	82.6 ± 4.1**	89.7 ± 4.4**#
70 mmHg	108.6 ± 9.1	41.0 ± 3.6	72.5 ± 3.8	82.1 ± 4.1**	80.6 ± 4.0**#
80 mmHg	110.2 ± 9.6	42.0 ± 3.7	81.3 ± 4.0	81.9 ± 3.5**	70.5 ± 3.5**
1.5 years old
Female
No treatment	123.3 ± 11.2	39.6 ± 3.5	37.5 ± 1.8	35.7 ± 1.7	33.9 ± 1.6
40 mmHg	122.1 ± 11.5	38.5 ± 3.4	42.5 ± 2.1	84.9 ± 2.7**	53.1 ± 2.6*
50 mmHg	119.5 ± 12.6	40.3 ± 3.6	51.6 ± 2.7	83.3 ± 3.6**	70.8 ± 3.5**##
60 mmHg	118.5 ± 13.2	40.2 ± 3.5	62.8 ± 3.1	81.6 ± 3.7**	76.1 ± 3.7**##
70 mmHg	132.2 ± 8.0	40.7 ± 3.6	71.4 ± 3.7	78.4 ± 3.9**	84.9 ± 3.9**##
80 mmHg	129.6 ± 8.2	41.2 ± 3.6	81.4 ± 4.0	78.6 ± 3.4**	69.1 ± 3.4*##
Male
No treatment	130.2 ± 10.2	41.0 ± 3.6	38.8 ± 1.9	36.9 ± 1.8	35.0 ± 1.7
40 mmHg	127.5 ± 7.2	39.6 ± 3.5	42.5 ± 2.1	85.7 ± 2.2**	56.3 ± 2.8*
50 mmHg	125.6 ± 6.8	40.3 ± 3.6	52.3 ± 2.8	80.9 ± 3.0**	75.1 ± 3.7**##
60 mmHg	126.9 ± 8.6	40.2 ± 3.5	62.9 ± 3.1	83.0 ± 3.6**	73.3 ± 3.6**##
70 mmHg	130.2 ± 6.2	39.6 ± 3.5	72.5 ± 3.8	81.7 ± 3.8**	79.1 ± 3.8 **##
80 mmHg	129.4 ± 9.2	39.6 ± 3.5	81.4 ± 4.05	84.3 ± 3.3**	66.5 ± 3.3**#

Data are mean ± standard deviation (n = 8/group). No treatment, no fluid infusion group control. Analysis of variance showed mean arterial pressure at the end of phases I and II had no significant change among all groups (among ages, genders and target resuscitation pressures), but at the end of phases III and IV there were significant differences between different target resuscitation pressures and ages (P < 0.01) but no significant differences between sexes. *P < 0.05; **P < 0.01versus no treatment group; #P < 0.05, ##P < 0.01 versus 40 mmHg group (post-hoc Tukey test).

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