Figure 1
From: 3,4-Diaminopyridine may improve neuromuscular block during botulism
Low compound muscle action potential amplitudes. Surface electromyograms were recorded bilaterally from right and left abductor pollicis brevis (ABP) and abductor digiti minimi (ADM) muscles following median and ulnar nerves supramaximal stimulation at the wrist. (a) Low compound muscle action potential (CMAP) amplitude mean values expressed as a percentage of the lower limit of normality range of the right and left APB and the right and left ADM ±1 standard error of the mean are represented according to timeline. No difference was observed between right and left sides. 3,4-Diaminopyridine (3,4-DAP) plasma concentrations are shown at +1.5 hours (H). Cases 1 and 2 received 20 mg 3,4-DAP, Case 3 received 10 mg (test dose). (b) Relation between time to extubation and CMAP mean values at day 21.