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Table 1 Physiological variables and peripheral neutrophil counts at baseline and 2 hours after mechanical ventilation and endotoxemia.a

From: Effects of ventilation strategy on distribution of lung inflammatory cell activity

 

Injurious ventilation (n= 6)

Protective ventilation (n= 6)

Parameter

Baseline

After MV + ETX

Baseline

After MV + ETX

VT, ml/kg

18.6 ± 3.9b

14.3 ± 4.4c

8.1 ± 0.2

8.0 ± 0.2

RR, breaths/min

19 ± 2b

21 ± 3c

25 ± 2

26 ± 2

PEEP, cmH2O

0b

0a

17 ± 3

17 ± 2

Mean airway pressure, cmH2O

10 ± 2b

10 ± 1b

20 ± 3

21 ± 2

FiO2

0.30 (0.30 to 0.35)

0.35 (0.30 to 0.62)

0.30 (0.30 to 0.40)

0.30 (0.30 to 0.42)

PaO2/FiO2, torrg

255 ± 74c

162 ± 67d

351 ± 117

261 ± 112

PaCO2, torr

33 (30 to 40)

43 (41 to 46)

39 (36 to 42)

39 (33 to 43)

Qs/Qt

0.24 (0.03 to 0.49)

0.60 (0.37 to 0.75)

0.15 (0.07 to 0.36)

0.37 (0.21 to 0.48)

Crs, ml/cmH2O

15.4 ± 6.8

11.4 ± 3.5

12.8 ± 2.7

12.2 ± 1.8

Heart rate, bpm

188 ± 30c

150 ± 41f

120 ± 26

137 ± 34

Cardiac output, L/min

4.3 ± 1.1

4.4 ± 0.7d

3.3 ± 0.7

3.1 ± 0.5

MAP, mmHg

92 ± 12

78 ± 13

87 ± 13

81 ± 13

MPAP, mmHg

16 ± 9

21 ± 5d

22 ± 6

32 ± 6e

PVR, dyn/s/cm5

228 ± 97

313 ± 109b

372 ± 108

579 ± 118f

Blood neutrophil count (103/μl)g

3.09 (1.32 to 3.96)

0.23 (0.14 to 0.25)e

1.80 (1.05 to 3.90)

0.20 (0.02 to 2.17)

  1. aMV, mechanical ventilation; ETX, endotoxin; VT, tidal volume; RR, respiratory rate; PEEP, positive end-expiratory pressure; FiO2, fraction of inspired oxygen; PaO2/FiO2, ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen; PaCO2, arterial carbon dioxide tension; Qs/Qt, venous admission calculated with the Berggren equation; Crs, respiratory system compliance; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PVR, pulmonary vascular resistance. Comparisons between both groups at the same time point: bP < 0.001, cP < 0.01 and dP < 0.05. Comparison between baseline and after mechanical ventilation and endotoxemia within each group: eP < 0.01 and fP < 0.05. gP < 0.05 for global effect of time. P values are derived from two-way analysis of variance with Bonferroni adjustments on post hoc tests.