Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study

Table 6 Logistic regression analysis of factors associated with AKI in patients who received CMS and NAs

		Univariate analysis			Multivariate analysis^b
Variables	No. AKI/total (%)	O.R.	95% C.I.	P -value	O.R.	95% C.I.	P -value
Age, years ^a
<64	36/110 (32)	1.00
≥64	49/112 (43)	1.59	0.92-2.75	0.09
Sex
Male	63/150 (42)	1.00
Female	22/72 (30)	0.6	0.33-1.1	0.1	0.6	0.29-1.2	0.15
SAPS II ^a
<44	25/109 (22)	1.00
≥44	60/113 (53)	3.8	2.13-6.79	<0.01	2.45	1.17-4.74	<0.01
Septic shock at Infection onset
No	19/121 (15)	1.00
Yes	66/101 (65)	10.12	5.34-19.12	<0.01	8.24	4.26-15.93	<0.01
Treatment with CMS
No	54/132 (41)	1.00
Yes	31/90 (34)	0.75	0.43-1.32	0.33

The variables included in the final predictive model were selected with a stepwise procedure: age was not included in the final model.
^a Age, SAPS II were dichotomized around median values.
^bThe ROC curve analysis was used to assess the goodness of the final logistic regression model (AUC = 0.8 ± 0.03 with 0.75 to 0.86 95% CI; Chi-square statistics: P <0.01)
AKI, acute kidney injury; AUC, area under the curve; CI, confidence interval; CMS, colistin methanesulfate; NAs, nephrotoxic antibiotics (aminoglycosides, glycopeptides); ROC, receiver operating characteristic; SAPS II, Simplified Acute Physiology Score Two (calculated 24 h after ICU admission).

ISSN: 1364-8535