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Table 1 Patient characteristics

From: A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia

 

Non-complicated FN (n = 79)

Septic shock (n = 20)

P

Gender (male: female)

44:35

12:8

NS**

Age (median, range)

49 (13 to 78)

52 (21 to 78)

NS**

Diagnostic NS**

Acute leukemia

30

10

 

Other hematolgical malignancies

49

10

 

Comorbidities (present:absent)

29:40

8:12

NS**

Treatment NS**

Intensive CTx/autologus HSCT

62

15

 

Allogeneic HSCT

17

5

 

Neutrophils/µl (median, range)

80 (0 to 500)

0 (0 to 500)

NS*

Platelets x10³/µl (median, range)

21,000

(4,000 to 215,000)

14,500

(3,000 to 39,000)

NS*

Agent isolation in bloodstream*** (yes:no)

27:52

7:13

NS**

C reactive protein mg/dl (median, range)

11.20 (0.55 to 58.30)

12.7 (6.2 to 40.90)

NS*

SOFA score (median, range)

4 (0 to 8)

4 (2 to 14)

P <0,05*

MASCC score (median, range)

19 (12 to 23)

18 (12 to 21)

NS*

Time to sample collection hours (median, range)

48 (3 to 120)

 

Time to septic shock days (median, range)

3 (1 to 17)

 
  1. CTx, chemotherapy; HSCT, hematopoietic stem cell transplantation; MASCC, Multinational Association for Supportive Care in Cancer; SOFA, Sequential Organ Failure Assessment; * Mann-Whitney test; ** Fisher's exact test; *** Gram-negative: Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Stenotrophomonas maltophilia. Gram-positive: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus viridans, Staphylococcus warneri, Staphylococcus haemolyticus. Fungi: Aspergillus e Fusarium.