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Table 2 Breathing pattern, respiratory muscle output and continuous positive airway pressure level during spontaneous breathing at clinical and two physiological settings of continuous positive airway pressure in the total population.a

From: Continuous positive airway pressure titration in infants with severe upper airway obstruction or bronchopulmonary dysplasia

 

Spontaneous breathing

Clinical CPAP

Physiological CPAP

Physiological CPAP+1 cmH2O

Respiratory parameters

    

  f R (breaths/min)

49 ± 14

44 ± 21

38 ± 16b

36 ± 18

  T I /T TOT

0.5 ± 0.1

0.4 ± 0.1

0.4 ± 0.1c

0.4 ± 0.1

Respiratory muscle output

    

  Poes swing (cmH2O)

31 ± 15

21 ± 10d

11 ± 5b

14 ± 6

  Pdi swing (cmH2O)

26 ± 8

20 ± 8d

12 ± 6b

15 ± 7

  Pgas swing (cmH2O)

4 ± 2

3 ± 1

2 ± 1c

2 ± 1

  Expiratory Pgas swing (cmH2O)

4 ± 4

3 ± 5

1 ± 1

2 ± 2

  PTPoes/breath (cmH2O/s)

12 ± 6

9 ± 6

6 ± 5b

9 ± 9

  PTPdi/breath (cmH2O/s)

11 ± 4

9 ± 6

6 ± 4b

8 ± 6

  PTPoes/min (cmH2O/s/min)

571 ± 340

359 ± 227

183 ± 119e

244 ± 161

  PTPdi/min (cmH2O/s/min)

452 ± 146

350 ± 164

201 ± 108b

239 ± 173

  CPAP level (cmH2O)

NA

8 ± 2

10 ± 2

11 ± 2

  1. aCPAP: continuous positive airway pressure, f R : respiratory rate, NA: not applicable, Poes: oesophageal pressure, Pdi: transdiaphragmatic pressure, Pgas: gastric pressure, PTP: pressure-time product, T I /T TOT : inspiratory time/total respiratory cycle time ratio. bP < 0.05 between physiological CPAP and spontaneous breathing or clinical CPAP. cP < 0.05 between spontaneous breathing and physiological CPAP. dP < 0.05 between spontaneous breathing and clinical CPAP. eP < 0.05 between physiological CPAP and spontaneous breathing, physiological CPAP or physiological CPAP+1 cmH2O.