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Table 1 Probability of 'presumably correct indication' (six-point score)

From: Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement

    

Criteria for 'presumably correct indication'

 

Patients (total, n)

Score

(Y, n)

Time interval (start <6 h)

Restricted to acute volume resuscitation (Duration)

Algorithm for fluid administration

Haemodynamic instability at randomisation

Maximum dose

Exclusion of renal failure/ RRT

Du, 2011 [4]

42

1

No

No

Y

No

No

No

Perner, 2012 (6S) [3]

804

1

No

No

No

No

Y

Nob

Brunkhorst, 2008 (VISEP) [1]a

537

2

No

No

Y

No

Noc

Yd

Myburgh, 2012 (CHEST) [2]

6,742

2

No

No

No

No

Y

Y

van der Heijden, 2009 [20]a

48

3

No

Y

Y

No

Y

n.a.

Dubin, 2010 [5]

20

4

Y

No

Y

Y

Ye

n.a.

Guidet, 2012 (CRYSTMAS) [18]

174

4

Y

No

Y

Yf

Y

Nog

James, 2011 (FIRST) [6]

109

4

Y

No

Y

Y

No

Y

McIntyre, 2008 (FINESS) [19]a

40

4

Y

No

Y

Y

Noh

Yi

Siegemund, 2013 (BaSES) [7]

241

4

Y

No

Y

n.a.

Y

Y

Vlachou, 2010 [21]a

26

4

Y

No

Y

No

Y

Y

  1. aMolecular weight was 200 kDa, which is known as an independent risk factor for mortality; bacute kidney injury, defined as renal SOFA score of ≥2, creatinine >1.9 mg/dL or urine output<500 mL/d, was present in up to 36% of patients; cinconsistencies between study protocol specifications and published baseline data in up to 38% of patients; drenal dysfunction (urine output ≤0.5 mL/kg/h for 1 h and/or serum creatinine >2 times normal ranges) was present in up to 10.9% of patients; edata for body weight are not provided, fpersonal communication; ginconsistencies between study protocol specifications and published baseline data in up to 68% of patients; hafter 12 h, the quantity and type of fluid administered were at the discretion of the treating physician; ilimited to chronic renal failure with renal replacement therapy. Y = Yes; n.a.= not assessed; RRT, renal replacement therapy.
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Critical Care

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