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Table 2 Pharmacokinetic parameters of amikacin loading dose according to the creatinine clearance (CrCl) at the onset of therapy

From: Therapeutic drug monitoring of amikacin in septic patients

Parameter

All patients (n= 63)

CrCl ≥50 mL/min (n= 46)

CrCl <50 mL/min (n= 17)

Vd (L)

26.32 (8.4-51.7)

25.7 (8.5-49.3)

38.8 (8.4-46.7)

Vd (L/kg)

0.42 (0.12-1.03)

0.40 (0.12-1.03)

0.66 (0.2-0.8)*

t 1/2 (h)

5.4 (0.8-19.9)

4.9 (0.8-11.0)

7.8 (3.2-19.1)*

CL (mL/min)

3.3 (0.6-25.3)

3.4 (1.5-25.8)

3.3 (0.6-9.9)

AUC 0-24 (mg*h/L)

462 (58-1867)

361 (58-1045)

507 (153-1867)

  1. Data are presented as median (ranges). *P = 0.05 vs. CrCl ≥50 mL/min. Vd, volume of distribution; t1/2 , half-life; CL, drug clearance; AUC0-24, area under the curve for the first day of therapy.