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Table 2 Pharmacokinetic parameters of amikacin loading dose according to the creatinine clearance (CrCl) at the onset of therapy

From: Therapeutic drug monitoring of amikacin in septic patients

Parameter All patients (n= 63) CrCl ≥50 mL/min (n= 46) CrCl <50 mL/min (n= 17)
Vd (L) 26.32 (8.4-51.7) 25.7 (8.5-49.3) 38.8 (8.4-46.7)
Vd (L/kg) 0.42 (0.12-1.03) 0.40 (0.12-1.03) 0.66 (0.2-0.8)*
t 1/2 (h) 5.4 (0.8-19.9) 4.9 (0.8-11.0) 7.8 (3.2-19.1)*
CL (mL/min) 3.3 (0.6-25.3) 3.4 (1.5-25.8) 3.3 (0.6-9.9)
AUC 0-24 (mg*h/L) 462 (58-1867) 361 (58-1045) 507 (153-1867)
  1. Data are presented as median (ranges). *P = 0.05 vs. CrCl ≥50 mL/min. Vd, volume of distribution; t1/2 , half-life; CL, drug clearance; AUC0-24, area under the curve for the first day of therapy.