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Table 1 Hemodynamic and echocardiographic parameters

From: Depletion of myocardial glucose is observed during endotoxemic but not hemorrhagic shock in a porcine model

  

Mean difference (CI)

P(mean)

Max difference (CI)

P(max)

HR (bpm)

C vs H

12.7(-1.7 to 27.2)

NS(0.081)

18.4(-1.3 to 38.2)

NS(0.066)

 

C vs E

16.3(2.0 to 30.5)

0.027

25.6(6.0 to 45.2)

0.013

 

H vs E

3.5(-10.6 to 17.7)

NS(0.609)

N/A

NS(0.151)

MAP (mmHg)

C vs H

-34.0(-44.7 to -23.3)

<0.001

-48.6(-61.4 to -35.8)

<0.001

 

C vs E

-9.8(-20.6 to 1.1)

NS(0.075)

-29.9(-42.8 to -17.0)

<0.001

 

H vs E

24.3(14.2 to 34.3)

<0.001

29.1(16.6 to 41.6)

<0.001

MPAP (mmHg)

C vs H

-3.5(-7.0 to -0.1)

0.047

unable to identify sig. changes

NS(0.107)

 

C vs E

10.9(7.2 to 14.7)

<0.001

19.4(14.4 to 24.4)

<0.001

 

H vs E

14.5(10.8 to 18.1)

<0.001

23.3(18.4 to 28.1)

<0.001

CVP (mmHg)

C vs H

-1.8(-3.4 to -0.2)

0.029

-2.4(-4.3 to -0.4)

0.020

 

C vs E

-0.3(-1.8 to 1.3)

NS(0.722)

N/A

NS(0.295)

 

H vs E

1.5(0.1 to 3.0)

0.041

2.9(1.0 to 4.7)

0.004

PCWP (mmHg)

C vs H

-2.4(-4.0 to -0.9)

0.004

-3.0(-5.0 to -0.9)

0.008

 

C vs E

0.5(-1.0 to 2.1)

NS(0.464)

2.9(0.9 to 5.0)

0.007

 

H vs E

3.0(1.5 to 4.4)

<0.001

5.1(3.2 to 7.1)

<0.001

SVI (ml/m2)

C vs H

-8.2(-12.5 to -3.8)

0.001

-10.5(-16.6 to -4.5)

0.002

 

C vs E

-6.0(-10.3 to -1.7)

0.008

-7.8(-13.8 to -1.7)

0.014

 

H vs E

2.1(-2.3 to 6.5)

NS(0.322)

5.4(-0.6 to 11.4)

NS(0.076)

SmvO2 (%)

C vs H

-23.8(-32.9 to -14.7)

<0.001

-33.4(-45.4 to -21.4)

<0.001

 

C vs E

-6.1(-15.2 to 3.0)

NS(0.178)

-14.9(-26.9 to -2.9)

0.017

 

H vs E

17.7(9.2 to 26.2)

<0.001

19.2(8.0 to 30.4)

0.002

A-Lac (mmol/L)

C vs H

2.3(0.6 to 4.1)

0.011

2.7(0.7 to 4.7)

0.010

 

C vs E

2.8(1.0 to 4.6)

0.003

3.3(1.3 to 5.3)

0.003

 

H vs E

0.5(-1.1 to 2.1)

NS(0.529)

N/A

NS(0.188)

DO2i (ml/min/m2)

C vs H

-96.2(-157.2 to -35.2)

0.004

-113.6(-185.7 to -41.5)

0.004

 

C vs E

1.6(-61.5 to 64.6)

NS(0.959)

N/A

NS(0.536)

 

H vs E

97.8(35.5 to 160.0)

0.004

120.1(47.0 to 193.1)

0.003

VO2i (ml/min/m2)

C vs H

0.7(-28.8 to 30.2)

NS(0.962)

N/A

NS(0.275)

 

C vs E

14.8(-17.0 to 46.6)

NS(0.343)

N/A

NS(0.242)

 

H vs E

14.1(-16.6 to 44.8)

NS(0.349)

N/A

NS(0.210)

O2ER

C vs H

0.2 (0.2 to 0.3)

<0.001

0.3(0.2 to 0.4)

<0.001

 

C vs E

0.1(0.0 to 0.2)

NS(0.119)

0.1(0.0 to 0.2)

0.029

 

H vs E

-0.2(-0.3 to -0.1)

<0.001

-0.2(-0.1 to -0.3)

0.001

LVSWI (g.mm2)

C vs H

-16.9(-22.6 to -11.2)

<0.001

-24.4(-31.4 to -17.3)

<0.001

 

C vs E

-9.1(-14.7 to -3.6)

0.003

-17.2(-24.2 to -10.3)

<0.001

 

H vs E

7.8(2.3 to 13.3)

0.008

9.5(2.3 to 16.7)

0.012

RVSWI (g.mm2)

C vs H

-2.2(-4.0 to -0.5)

0.016

-2.6(-4.9 to -0.3)

0.031

 

C vs E

2.0(0.2 to 3.8)

0.027

4.9(2.6 to 7.2)

<0.001

 

H vs E

4.2(2.5 to 6.0)

<0.001

7.5(5.2 to 9.7)

<0.001

EF (%)

C vs H

2.9(-1.8 to 7.5)

NS(0.210)

N/A

NS(0.263)

 

C vs E

-9.5(-14.4 to -4.7)

0.001

-10.5(-16.6 to -4.5)

0.002

 

H vs E

-12.4(-17.0 to -7.8)

<0.001

-13.1(-18.9 to -7.4)

<0.001

TDI (mm)

C vs H

-0.5(-1.1 to 0.2)

NS(0.143)

-1.0(-2.1 to 0.0)

NS(0.055)

 

C vs E

-0.4(-1.1 to 0.2)

NS(0.182)

-1.0(-2.2 to 0.2)

NS(0.092)

 

H vs E

0.0(-0.6 to 0.7)

NS(0.943)

N/A

NS(0.462)

VTI (cm)

C vs H

-4.0(-6.3 to -1.8)

0.001

-5.7(-8.4 to -3.1)

<0.001

 

C vs E

-2.2(-4.5 to 0.1)

NS(0.056)

-2.8(-5.6 to 0.0)

0.048

 

H vs E

1.8(-0.4 to 4.0)

NS(0.099)

3.8(1.3 to 6.3)

0.005

TAPSE (mm)

C vs H

-1.2(-3.5 to 1.0)

0.268

-2.7(-5.5 to 0.1)

NS(0.060)

 

C vs E

-3.0(-5.1 to -0.9)

0.008

-4.0(-6.7 to -1.3)

0.006

 

H vs E

-1.8(-3.9 to 0.4)

NS(0.105)

-3.3(-5.9 to -0.6)

0.018

TR (mmHg)

C vs H

-1.7(-10.7 to 7.3)

NS(0.695)

N/A

NS(0.441)

 

C vs E

8.3(-0.8 to 17.4)

NS(0.070)

10.3(-0.4 to 21.1)

NS(0.059)

 

H vs E

10.0(2.0 to 18.1)

0.018

14.5(5.0 to 24.0)

0.005

E/A

C vs H

0.1(-0.2 to 0.4)

NS(0.491)

N/A

NS(0.098)

 

C vs E

-0.3(-0.7 to 0.0)

0.034

-0.5(-0.8 to -0.1)

0.015

 

H vs E

-0.5(-0.8 to -0.2)

0.005

-0.6(-1.0 to -0.2)

0.004

E/é

C vs H

2.5(0 to 5.1)

0.051

4.0(0.3 to 7.7)

0.036

 

C vs E

-1.5(-4.1 to 1.1)

NS(0.236)

N/A

NS(0.066)

 

H vs E

-4.0(-1.6 to -6.5)

0.002

-5.5(-8.9 to -2.1)

0.003

  1. Mean and maximum differences from baseline and CI are given. A positive mean or maximum difference indicates increased values in H or E groups compared to controls (C versus H and C versus E) and vice versa. Similarly, for H versus E a positive mean or maximum difference indicates an increase in the E group compared to the H group. P(mean) refers to intergroup differences over time using mixed models analysis. P(max) refers to post-hoc analyses at the time of maximal difference and are given as unadjusted P-values. A-lac, arterial lactate concentration; C, control group; CVP, central venous pressure; DO2i, oxygen delivery index; E; endotoxemic group; E/A, mitral early to late flow ratio; E/é, mitral early flow to tissue Doppler velocity ratio; EF, ejection fraction; H, hemorrhagic group; HR,heart rate; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; NS, non-significant; O2ER, oxygen extraction ratio; PCWP, pulmonary capillary wedge pressure; RVSWI, right ventricular stroke work index; SmvO2, mixed venous oxygen saturation; SVI, stroke volume index; TAPSE, tricuspid annular plane systolic excursion; TDI, average (septal and lateral) tissue Doppler velocity; TR, right atrial-right ventricular pressure gradient measured using tricuspid regurgitation; VO2i, oxygen consumption index; VTI, velocity time integral at the left ventricular outflow tract.