Feasibility of fully automated closed-loop glucose control using continuous subcutaneous glucose measurements in critical illness: a randomized controlled trial

Table 1 Local intravenous insulin titration protocol

Blood glucose (mM)	Insulin infusion rates^a (Units/hour)
20.0	6.0, inform physician^b
17.1-20.0	4.0, inform physician^b
14.1-17.0	3.0, inform physician^b
11.1-14.0	2.5, inform physician^b
8.6-11.0	2.0, inform physician^b if glucose >10
7.1-8.5	1.5
5.6-7.0	1.0
4.0-5.5	0.5
<4.0	NIL, inform physician^b

a50 Units Insulin Actrapid in 50 ml of 0.9% saline. bTarget glucose was 7 to 10 mM, and when the glucose was outside this target, hourly infusion rates were adjusted by the attending physician.

ISSN: 1364-8535