CD8+T-cell counts: an early predictor of risk and mortality in critically ill immunocompromised patients with invasive pulmonary aspergillosis

Table 7 Receiver operating characteristic curve analysis of immune parameters predicting 28-day mortality in critically ill immunocompromised patients with invasive pulmonary aspergillosis ^a

Parameters^b(cells/mm³)	28-day mortality from D1 (n = 62)			28-day mortality from D3 (n = 51)			28-day mortality from D10 (n = 40)
	Cutoff value (cells/mm³)	AUC (95% CI)	Pvalue	Cutoff value (cells/mm³)	AUC (95% CI)	Pvalue	Cutoff value (cells/mm³)	AUC (95% CI)	Pvalue
NK		–		41.0	0.78 (0.66 to 0.91)	0.001	23.0	0.73 (0.57 to 0.90)	0.013
CD3⁺ T	215.0	0.68 (0.55 to 0.82)	0.017	235.5	0.77 (0.64 to 0.90)	0.001	243.0	0.75 (0.59 to 0.91)	0.007
CD28⁺CD4⁺ T		–		61.5	0.70 (0.55 to 0.85)	0.015	108.5	0.69 (0.52 to 0.87)	0.040
CD8⁺ T	149.5	0.82 (0.71 to 0.92)	<0.001	96.5	0.94 (0.87 to 0.99)	<0.001	90.5	0.94 (0.85 to 0.99)	<0.001
CD28⁺CD8⁺ T	75.0	0.84 (0.75 to 0.94)	<0.001	56.5	0.92 (0.85 to 0.99)	<0.001	46.0	0.90 (0.79 to 0.99)	<0.001

^aAUC area under the curve, CI confidence interval, D1 day 1, D3 day 3, D10 day 10, NK natural killer. ^bVariable included the immune parameters that differed significantly between survivors and nonsurvivors in critically ill immunocompromised patients with invasive pulmonary aspergillosis according to 28-day mortality (Table 6).

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