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Table 3 Microbiological characteristics of critically ill immunocompromised patients a

From: CD8+T-cell counts: an early predictor of risk and mortality in critically ill immunocompromised patients with invasive pulmonary aspergillosis

Variables

All patients (n = 150)

No IPA (n = 88, 58.7%)

IPA (n = 62, 41.3%)

No IPA vs IPA Pvalue

Sites of infection, n (%)

    

 Lung

113 (75.3)

66 (75.0)

47 (75.8)

>0.999

 Lung and BSIb

33 (22.0)

19 (21.6)

14 (22.6)

>0.999

 Lung, BSI and intraabdominal

2 (1.3)

1 (1.1)

1 (1.6)

-

 Lung, BSI and urogenital

1 (0.7)

1 (1.1)

0

-

 Lung, BSI and soft tissue (skin)

1 (0.7)

1 (1.1)

0

-

Positive chest CT findings,cn (%)

100 (66.7)

47 (53.4)

53 (85.5)

<0.001

 Radiologist 1,dn = 85 (100%)

55 (64.7)

27 (52.9)

28 (82.4)

0.006

 Radiologist 2,en = 65 (100%)

45 (69.2)

20 (54.1)

25 (89.3)

0.003

Specific chest CT findings,fn (%)

35 (23.3)

9 (10.2)

26 (41.9)

<0.001

 Radiologist 1,dn = 85 (100%)

19 (22.4)

5 (9.8)

14 (41.2)

0.007

 Radiologist 2,en = 65 (100%)

16 (24.6)

4 (10.8)

12 (42.9)

0.001

CPIS score at ICU admission

8.3 (3.0)

8.2 (4.0)

8.6 (2.5)

0.161

Infection marker at ICU admission

    

 PCT level (ng/ml)

1.1 (4.2)

0.9 (4.1)

1.5 (4.4)

0.35

 BG level (pg/ml)

5.0 (15.8)

5.0 (11.5)

5.0 (38.6)

0.26

 CRP level (mg/L)

92.7 ± 73.5

90.9 ± 76.9

95.5 ± 68.4

0.718

Coexisting pathogens, n (%)

    

 CMVg

55 (36.7)

27 (30.7)

28 (45.2)

0.086

 PCP

20 (13.3)

8 (9.1)

12 (19.4)

0.088

 Candida species

60 (40.0)

40 (45.5)

20 (32.3)

0.128

 MDR GNBh

99 (66.0)

55 (62.5)

44 (71.0)

0.299

 GPB

43 (28.7)

21 (23.9)

22 (35.5)

0.144

 GNBi

122 (81.3)

70 (79.5)

52 (83.9)

0.532

  1. aBG (1,3)-β-d-glucan, BSI bloodstream infection, CMV cytomegalovirus, CPIS Clinical Pulmonary Infection Score, CRP C-reactive protein, CT computed tomography, GNB Gram-negative bacteria, GPB Gram-positive bacteria, IPA invasive pulmonary aspergillosis, MDR multi-drug-resistant, PCP Pneumocystis carinii pneumonia, PCT procalcitonin. Continuous variables are expressed as the mean ± SD or the medians (IQR). All other data are raw numbers (%). bVariable defined as recovery of any bacterium or fungus in one or more blood cultures taken in the presence of clinical evidence of infection following ICU admission. Patients in whom Staphylococcus (non-S. aureus) was isolated from blood cultures were not eligible, except if two or more consecutive samples grew the same species harboring the same antibiotic resistance pattern [10]. cVariable defined as patients who developed a new and persistent radiographic infiltrate. dThe proportion of 85 critically ill immunocompromised (CIIC) patients with positive and specific chest CT findings in the IPA and non-IPA groups defined by radiologist 1. eThe proportions of 65 CIIC patients with positive and specific chest CT findings in the IPA and non-IPA groups defined by radiologist 2. fSpecific chest CT findings of IPA were defined according to the 2008 EORTC-MSG criteria [6]: a well-defined dense lesion (with or without a halo sign), a crescent sign and a cavity. gIncluding patients with a positive CMV pp65 antigen, polymerase chain reaction or immunoglobulin M detection. hVariable included MDR Pseudomonas aeruginosa, MDR Acinetobacter baumannii and MDR Klebsiella pneumoniae. iVariable defined as all GNB except MDR GNB.
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Critical Care

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