| Usual care | Intervention | Difference | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Outcome measure | Time point | n | Mean change | ES* | n | Mean change | ES | Difference | 95% CI | ES** |
6MWT (m) | 3 months | 49 | 184.25 | 1.67 | 47 | 247.93 | 3.59 | 63.67 | 14.17 to 113.18+ | 0.53 |
12 months | 35 | 219.49 | 1.98 | 40 | 292.04 | 4.40 | 72.55 | 9.29 to 135.81+ | 0.54 | |
TUG (s) | 3 months | 51 | −23.37 | 0.55 | 50 | −31.68 | 0.72 | −8.31 | −24.90 to 8.28 | 0.20 |
12 months | 38 | −19.52 | 0.47 | 44 | −29.09 | 0.69 | −9.57 | −27.42 to 8.28 | 0.24 | |
AQoL utility | 3 months | 53 | −0.08 | 0.27 | 43 | 0.037 | 0.15 | 0.12 | −0.03 to 0.26 | 0.33 |
12 months | 48 | −0.11 | 0.36 | 40 | 0.031 | 0.12 | 0.14 | –-.03 to 0.31 | 0.36 | |
SF-36v2 PF | 3 months | 45 | −3.2 | 0.24 | 39 | 3.64 | 0.24 | 6.8 | 1.2 to 12.5+ | 0.53 |
12 months | 35 | 0.39 | 0.03 | 33 | 3.88 | 0.27 | 3.5 | −3.5 to 10.5 | 0.25 | |
PCS | 3 months | 45 | −2.26 | 0.19 | 38 | 3.33 | 0.26 | 5.6 | 0.09 to 11.1+ | 0.45 |
12 months | 35 | 3.33 | 0.28 | 32 | 6.46 | 0.49 | 3.1 | −3.2 to 9.5 | 0.25 | |
MCS | 3 months | 44 | 3.12 | 0.24 | 38 | 5.56 | 0.41 | 2.4 | −3.6 to 8.5 | 0.18 |
 | 12 months | 35 | 2.59 | 0.19 | 32 | 7.50 | 0.57 | 4.9 | −2.7 to 12.5 | 0.32 |