|
Characteristic
|
ALI/ARDS (n= 78)
|
CPE (n= 28)
|
Pvalue
|
|---|
|
Demographics
| | | |
|
Age (years)
|
63 (54 to 68)
|
66 (58 to 72)
|
0.231
|
|
Male
|
45 (57.7)
|
15 (53.6)
|
0.706
|
|
Body mass index (kg/m2)
|
23 (19 to 26)
|
23 (18 to 26)
|
0.297
|
|
Comorbidities
| | | |
|
Post operation
|
16 (20.5)
|
4 (14.3)
|
0.659
|
|
Atrial fibrillation
|
5 (6.4)
|
6 (21.4)
|
0.025*
|
|
Coronary artery disease
|
13 (16.7)
|
7 (25.0)
|
0.334
|
|
Chronic obstructive pulmonary disease
|
14 (17.9)
|
3 (10.7)
|
0.552
|
|
Hypertension
|
22 (28.2)
|
6 (21.4)
|
0.485
|
|
Diabetes
|
20 (25.6)
|
5 (17.9)
|
0.405
|
|
Chronic kidney disease
|
8 (10.3)
|
2 (7.1)
|
0.915
|
|
APACHE II score
|
18 (14 to 22)
|
15 (13 to 18)
|
0.067
|
|
SOFA score
|
8 (5 to 10)
|
4 (3 to 7)
|
0.037*
|
|
Ventilatory data
| | | |
|
Mechanical ventilation
|
49 (62.8)
|
15 (53.6)
|
0.391
|
|
Arterial pH
|
7.36 (7.31 to 7.42)
|
7.41 (7.37 to 7.48)
|
0.398
|
|
Arterial lactate
|
1.8 (1.1 to 2.3)
|
1.5 (1.2 to 1.9)
|
0.165
|
|
PO2/FiO2
|
166 (132 to 202)
|
224 (176 to 268)
|
0.033*
|
|
Echocardiography
| | | |
|
Patients examined
|
65 (83.3)
|
25 (89.3)
|
0.450
|
|
LVEF (%)
|
55 (51 to 61)
|
48 (41 to 53)
|
0.038*
|
|
Hemodynamics
| | | |
|
Patients examined
|
31 (39.7)
|
12 (42.9)
|
0.773
|
|
PAOP (mmHg)
|
14 (9 to 16)
|
23 (21 to 25)
|
0.042*
|
|
Cardiac index (l/min/m2)
|
3.01 (2.55 to 3.18)
|
2.85 (2.56 to 3.12)
|
0.671
|
|
SvO2 (%)
|
61 (53 to 66)
|
67 (60 to 73)
|
0.091
|
|
Laboratory findings
| | | |
|
White blood cell (109/l)
|
12.1 (8.6 to 14.8)
|
9.3 (6.3 to 12.5)
|
0.315
|
|
Platelet (109/l)
|
182 (137 to 255)
|
191 (155 to 257)
|
0.871
|
|
APTT (seconds)
|
30 (24 to 37)
|
31 (26 to 35)
|
0.672
|
|
Bilirubin (μmol/l)
|
11.7 (7.2 to 16.8)
|
9.1 (6.8 to 13.9)
|
0.774
|
|
Glucose (mmol/l)
|
6.7 (5.2 to 7.0)
|
6.5 (5.3 to 6.9)
|
0.781
|
|
Albumin (g/l)
|
28.2 (26.1 to 30.6)
|
30.2 (26.1 to 33.8)
|
0.317
|
|
Creatinine (μmol/l)
|
71 (55 to 88)
|
76 (55 to 91)
|
0.225
|
|
HBP (ng/ml)
|
17.15 (11.95 to 24.07)
|
9.50 (7.98 to 12.18)
|
<0.001*
|
|
Length of ICU stay (days)
|
9 (5 to 15)
|
7 (4 to 12)
|
0.221
|
- Data presented as median (interquartile range) for continuous variables and number (%) for categorical variables. ALI, acute lung injury; APACHE, Acute Physiology and Chronic Health Evaluation; APTT, activated partial thromboplastin time; ARDS, acute respiratory distress syndrome; CPE, cardiogenic pulmonary edema; HBP, heparin-binding protein; LVEF, left ventricular ejection fraction; PAOP, pulmonary artery occlusion pressure; PO2/FiO2, ratio of arterial oxygen partial pressure and inspiratory oxygen fraction; SOFA, Sequential Organ Failure Assessment; SvO2, oxygen saturation of venous blood. *P <0.05.
