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Table 1 Baseline characteristics of patients with ALI/ARDS or CPE

From: Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Characteristic

ALI/ARDS (n= 78)

CPE (n= 28)

Pvalue

Demographics

   

  Age (years)

63 (54 to 68)

66 (58 to 72)

0.231

  Male

45 (57.7)

15 (53.6)

0.706

  Body mass index (kg/m2)

23 (19 to 26)

23 (18 to 26)

0.297

Comorbidities

   

  Post operation

16 (20.5)

4 (14.3)

0.659

  Atrial fibrillation

5 (6.4)

6 (21.4)

0.025*

  Coronary artery disease

13 (16.7)

7 (25.0)

0.334

  Chronic obstructive pulmonary disease

14 (17.9)

3 (10.7)

0.552

  Hypertension

22 (28.2)

6 (21.4)

0.485

  Diabetes

20 (25.6)

5 (17.9)

0.405

  Chronic kidney disease

8 (10.3)

2 (7.1)

0.915

  APACHE II score

18 (14 to 22)

15 (13 to 18)

0.067

  SOFA score

8 (5 to 10)

4 (3 to 7)

0.037*

Ventilatory data

   

  Mechanical ventilation

49 (62.8)

15 (53.6)

0.391

  Arterial pH

7.36 (7.31 to 7.42)

7.41 (7.37 to 7.48)

0.398

  Arterial lactate

1.8 (1.1 to 2.3)

1.5 (1.2 to 1.9)

0.165

  PO2/FiO2

166 (132 to 202)

224 (176 to 268)

0.033*

Echocardiography

   

  Patients examined

65 (83.3)

25 (89.3)

0.450

  LVEF (%)

55 (51 to 61)

48 (41 to 53)

0.038*

Hemodynamics

   

  Patients examined

31 (39.7)

12 (42.9)

0.773

  PAOP (mmHg)

14 (9 to 16)

23 (21 to 25)

0.042*

  Cardiac index (l/min/m2)

3.01 (2.55 to 3.18)

2.85 (2.56 to 3.12)

0.671

  SvO2 (%)

61 (53 to 66)

67 (60 to 73)

0.091

Laboratory findings

   

  White blood cell (109/l)

12.1 (8.6 to 14.8)

9.3 (6.3 to 12.5)

0.315

  Platelet (109/l)

182 (137 to 255)

191 (155 to 257)

0.871

  APTT (seconds)

30 (24 to 37)

31 (26 to 35)

0.672

  Bilirubin (μmol/l)

11.7 (7.2 to 16.8)

9.1 (6.8 to 13.9)

0.774

  Glucose (mmol/l)

6.7 (5.2 to 7.0)

6.5 (5.3 to 6.9)

0.781

  Albumin (g/l)

28.2 (26.1 to 30.6)

30.2 (26.1 to 33.8)

0.317

  Creatinine (μmol/l)

71 (55 to 88)

76 (55 to 91)

0.225

  HBP (ng/ml)

17.15 (11.95 to 24.07)

9.50 (7.98 to 12.18)

<0.001*

  Length of ICU stay (days)

9 (5 to 15)

7 (4 to 12)

0.221

  1. Data presented as median (interquartile range) for continuous variables and number (%) for categorical variables. ALI, acute lung injury; APACHE, Acute Physiology and Chronic Health Evaluation; APTT, activated partial thromboplastin time; ARDS, acute respiratory distress syndrome; CPE, cardiogenic pulmonary edema; HBP, heparin-binding protein; LVEF, left ventricular ejection fraction; PAOP, pulmonary artery occlusion pressure; PO2/FiO2, ratio of arterial oxygen partial pressure and inspiratory oxygen fraction; SOFA, Sequential Organ Failure Assessment; SvO2, oxygen saturation of venous blood. *P <0.05.
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