Low-flow CO2removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements

Table 5 Hemodynamic parameters from the beginning ( t = 0 h), 4 hours ( t = 4 h), and 24 hours ( t = 24 h) after starting low-flow CO₂removal

Number	MAP (mm Hg)			Heart rate			Norepinephrine (mg/h)			Norepinephrine (μg/kg/min)			Lactate (mg/dl)
	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h
1	83	73	66	120	110	100	2.6	3.2	5.2	0.48	0.59	0.96	49	59	124
2	57	73	80	120	110	125	0.2	0.2	0.4	0.04	0.04	0.08	12	12	4.2
3	80	87	73	80	85	90	0.2	0.0	0.0	0.06	0.00	0.00	7	9	6
4	80	80	87	110	105	100	0.6	0.5	0.3	0.13	0.10	0.06	14	16	18
5	73	76^a	n.a.	110	100 ^a	n.a.	0.2	0.3 ^a	n.a.	0.04	0.06 ^a	n.a.	11	9 ^a	n.a.
6	70	77	93	110	90	90	5.0	2.0	1.0	0.93	0.37	0.18	43	47	12
7	70	73	90	70	65	95	0.1	0.0	0.0	0.02	0.00	0.00	6	7	9
8	66	63	73	110	90	90	1.2	1.2	0.9	0.17	0.17	0.13	12	13	14
9	80	82	73	105	110	110	0.0	0.0	0.0	0.00	0.00	0.00	7	7	8
10	73	87	93	100	85	80	1.9	0.9	0.0	0.32	0.15	0.00	10	12	9
Mean	73.20	77.22	80.89	103.50	94.44	97.78	n.a.	n.a.	n.a.	0.22	0.16	0.16	17.10	20.22	22.69

n.a., not applicable. Patient 5 was switched to ECMO after 2.5 hours of treatment and was therefore excluded from calculation of means at t = 4 hours and t = 24 hours.
^at = 2.5 hours.

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