Low-flow CO2removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements

Table 4 Ventilator settings from the beginning ( t = 0 hours), 4 hours ( t = 4 hours) and 24 hours ( t = 24 hours) after starting low-flow CO₂removal

Number	FiO₂(%)			PEEP (mm Hg)			Tidal volume (ml/pbw)			P_mean(mm Hg)			P_max(mm Hg)			Breathing rate
	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h	t = 0 h	t = 4 h	t = 24 h
1	0.85	0.95	1.00	14	14	14	8.6	8.0	8.6	22	22	23	32	32	32	25	23	20
2	1.00	0.95	1.00	14	16	20	7.5	5.8	5.1	22	22	23	32	32	30	22	22	30
3	0.55	0.55	0.50	10	10	10	8.3	8.2	7.6	19	18	19	35	32	34	30	28	28
4	0.40	0.40	0.35	8	8	8	8.2	8.2	7.2	17	17	15	32	31	27	20	20	20
5	1.00	1.00^a	n.a.	13	13 ^a	n.a.	8.6	6.5 ^a	n.a.	23	23 ^a	n.a.	40	40 ^a	n.a.	20	24 ^a	n.a.
6	1.00	0.95	0.60	12	12	12	9.0	8.8	8.0	20	19	19	34	33	31	20	20	20
7	0.37	0.37	0.37	12	12	10	9.6	9.5	8.1	16	14	13	27	23	21	12	12	14
8	0.50	0.50	0.50	15	15	15	9.8	8.4	6.7	21	21	21	33	33	30	20	20	26
9	0.80	0.70	0.60	12	12	14	7.9	9.6	7.7	19	19	18	28	28	25	28	28	24
10	0.40	0.40	0.50	12	12	12	6.6	8.6	7.1	19	19	18	32	32	28	26	26	26
Mean	0.69	0.64	0.60	12.20	12.33	12.78	8.41	8.34	7.34	19.80	19.00	18.78	32.50	30.67	28.67	22.30	22.11	23.11

n.a., not applicable. Patient 5 was switched to ECMO after 2.5 hours of treatment and was therefore excluded from calculation of means at t = 4 hours and t = 24 hours. ^at = 2.5 hours.

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