Low-flow CO2removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements

Table 2 Treatment modalities for low-flow CO ₂ removal integrated into the RRT circuit

No.	Double-lumen catheter	Blood flow (ml/min)		Dialysate flow (L/h)		Ultrafiltration (ml/h)		Volume (ml)	Gas flow (L/min)	Oxy FiO₂(vol. %)	Treatment time (hours)
		t = 4 h	t = 24 h	t = 4 h	t = 24 h	t = 4 h	t = 24 h	t = 24 h
1	1	250	300	4.0	4.0	100	200	−645	6	1.00	30
2	1	330	400	2.0	2.0	200	0	−705	4	1.00	84
3	1	400	400	2.0	2.0	0	150	605	4	0.50	45
4	1	400	400	2.0	2.0	0	100	1,715	6	0.40	215
5	2	300^a	n.a.	2.0 ^a	n.a.	100 ^a	n.a.	n.a.	6	0.21	2.5
6	1	500	450	3.0	3.0	0	100	1,340	6	0.21	191
7	1	320	250	2.0	2.0	100	150	−3,345	4	0.21	83
8	2	400	450	2.0	1.5	40	100	−2,055	6	0.21	71
9	1	400	500	2.0	2.0	0	0	180	6	0.21	92
10	1	250	250	2.0	2.0	50	0	2,945	4	0.21	134

Patient 5 was switched to ECMO after 2.5 hours of treatment and was therefore not applicable at t = 4 hours and t = 24 hours. ^at = 2.5 hours. n.a., not applicable.

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