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Table 2 For all parameters, reported are the value before ('Baseline') and after ('Final') each ventilation strategy, summarized as mean (standard deviation).

From: Cardiac index and oxygen delivery during low and high tidal volume ventilation strategies in patients with acute respiratory distress syndrome: a crossover randomized clinical trial

Parameter

Low VT strategy

High VT strategy

Low vs. high TV

 

Baseline

Final

Baseline

Final

Difference P value

 

Tidal volume (L)

0.49 (0.1)

0.42 (0.07)

0.50 (0.1)

0.72 (0.18)

-0.30

<0.001

Tidal volume/ideal body weight (mL/kg)

8 (2)

7 (1)

8 (2)

12 (3)

-5

<0.001

Respiratory rate (1/min)

22 (3)

25 (5)

22 (5)

15 (5)

10

<0.001

Minute ventilation (L)

10.9 (2.2)

10.7 (2.3)

10.7 (2.2)

10.2 (2.3)

0.5

0.262

Peak airway pressure (cmH2O)

27 (4)

26 (4)

28 (7)

35 (7)

-9

<0.001

Mean airway pressure (cmH2O)

19 (4)

18 (4)

20 (4)

22 (5)

-3

0.021

Dead space/tidal volume ratio

0.61 (0.14)

0.62 (0.14)

0.58 (0.15)

0.52 (0.14)

0.10

0.001

pH

7.37 (0.12)

7.37 (0.14)

7.38 (0.13)

7.41 (0.12)

-0.04

0.001

PaCO2 (mmHg)

47 (13)

49 (15)

48 (14)

43 (12)

6

0.002

PaO2 (mmHg)

124 (49)

131 (58)

120 (38)

117 (47)

14

0.020 a

Heart rate (1/min)

92 (16)

92 (15)

91 (17)

93 (19)

-1

0.521

Mean arterial pressure (mmHg)

78 (10)

75 (13)

78 (14)

77 (12)

-2

0.514

Cardiac index (L.min-1.m-2)

3.8 (1.3)

3.9 (1.2)

3.9 (1.2)

3.5 (1.1)

0.4

0.012

Central venous pressure (mmHg)

12 (5)

11 (5)

12 (4)

12 (5)

-1

0.176

Systemic vascular resistance index (dyne.sec.cm-5.m-2)

1494 (500)

1374 (312)

1455(432)

1572 (469)

-198

0.008

Oxygen delivery index (mL.min-1.m-2)

506 (181)

521 (187)

509 (145)

463 (146)

58

0.002

Oxygen consumption index (mL.min-1.m-2)

171 (55)

172 (43)

182 (50)

186 (43)

-14

0.239

Carbon dioxide production index (mL.min-1.m-2)

115 (24)

110 (24)

120 (24)

122 (24)

-12

0.002

Oxygen extraction ratio

0.37 (0.13)

0.36 (0.08)

0.37 (11)

0.44 (0.11)

-0.07

0.027

Central venous saturation (%)

77 (9)

77 (8)

78 (8)

74 (9)

2

0.120

Arterial lactate (mmol/L)

1.6 (0.9)

1.5 (0.8)

1.5 (0.8)

1.6 (0.9)

-0.1

0.028

  1. Reported is also the within-patient difference between the value after low TV and the value after high TV ('Low vs. High TV'), with P value from the analysis of variance adjusted for baseline. In bold are P values < 0.05.
  2. aAnalysis performed on log-transformed variable.