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Table 2 Initial antibiotherapy

From: Factors influencing the implementation of antibiotic de-escalation and impact of this strategy in critically ill patients

Initial antibiotics, number (percentage) All patients
(n = 229)
De-escalation
(n = 117)
No de-escalation
(n = 112)
P value
Group A penicillins 99 (43.2) 30 (25.6) 69 (61.6) <0.001
Carbapenems 10 (4.4) 8 (6.8) 2 (1.8) <0.001
Carboxy and ureido-penicillins 39 (17.0) 20 (17.1) 19 (17.0) 0.8
Fluoroquinolones 112 48.9) 78 (66.7) 34 (30.4) <0.001
Glycopeptides, linezolid 45 (19.6) 28 (23.9) 17 (15.2) 0.01
Cephalosporins 76 (33.2) 56 (47.9) 20 (17.9) <0.001
Macrolides 15 (6.6) 13 (11.1) 2 (1.8) <0.001
Aminoglycosides 17 (7.4) 8 (6.8) 9 (8.0) 0.7
Nitroimidazole 19 (8.3) 12 (10.3) 7 (6.3) 0.05
Others
Number of antibiotics
11 (4.8) 8 (6.8) 3 (2.7) 0.003
   1 79 (34.5) 11 (9.4) 68 (60.7) <0.001
   2 93 (40.6) 73 (62.4) 20 (17.9) <0.001
   3 50 (21.8) 28 (23.9) 22 (19.6) 0.2
   4 5 (2.2) 4 (3.4) 1 (0.9) <0.001
   5 2 (0.9) 1 (0.9) 1 (0.9) 0.9