Table 2 Initial antibiotherapy
Initial antibiotics, number (percentage) | All patients (n = 229) | De-escalation (n = 117) | No de-escalation (n = 112) | P value |
|---|---|---|---|---|
Group A penicillins | 99 (43.2) | 30 (25.6) | 69 (61.6) | <0.001 |
Carbapenems | 10 (4.4) | 8 (6.8) | 2 (1.8) | <0.001 |
Carboxy and ureido-penicillins | 39 (17.0) | 20 (17.1) | 19 (17.0) | 0.8 |
Fluoroquinolones | 112 48.9) | 78 (66.7) | 34 (30.4) | <0.001 |
Glycopeptides, linezolid | 45 (19.6) | 28 (23.9) | 17 (15.2) | 0.01 |
Cephalosporins | 76 (33.2) | 56 (47.9) | 20 (17.9) | <0.001 |
Macrolides | 15 (6.6) | 13 (11.1) | 2 (1.8) | <0.001 |
Aminoglycosides | 17 (7.4) | 8 (6.8) | 9 (8.0) | 0.7 |
Nitroimidazole | 19 (8.3) | 12 (10.3) | 7 (6.3) | 0.05 |
Others Number of antibiotics | 11 (4.8) | 8 (6.8) | 3 (2.7) | 0.003 |
1 | 79 (34.5) | 11 (9.4) | 68 (60.7) | <0.001 |
2 | 93 (40.6) | 73 (62.4) | 20 (17.9) | <0.001 |
3 | 50 (21.8) | 28 (23.9) | 22 (19.6) | 0.2 |
4 | 5 (2.2) | 4 (3.4) | 1 (0.9) | <0.001 |
5 | 2 (0.9) | 1 (0.9) | 1 (0.9) | 0.9 |